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Aging brain
About: Aging brain is a research topic. Over the lifetime, 1255 publications have been published within this topic receiving 66405 citations.
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TL;DR: In this paper, the authors found that the amount of splice variants of ERα in the hypothalamus and the hippocampus is increased in aging and decreased in AD, while ERα is one of the regulators of AS and is subject to AS itself.
Abstract: Human genes show the highest efficacy of alternative splicing (AS) in the brain as compared to other tissues. Within the brain, a remarkably rich diversity of AS events was identified in the hypothalamus. The AS frequency is increased in the aging brain. Such AS events, as intron retention and accumulation of circular RNAs, were acknowledged as some of the main hallmarks of the aging brain. In Alzheimer's disease (AD) pivotal (tau gene, in particular), risk, candidate and other genes show significant alterations in AS. Therefore AD has been suggested to be a disease of dysregulated AS. One of the reported risk factors for AD is estrogen deficiency that may interfere with the extension of neurobrillary tangles. Mounting evidence suggests that estrogens may decrease hyperphosphorylated tau deposition in the brain. Furthermore, AS of estrogen receptor α (ERα) mRNA is decreased in AD brain areas with the highest tau load. These potential interactions among tau, estrogens, and ERα AS may be important for the development of therapeutic and preventive strategies for AD. The intriguing point is that the amount of splice variants of ERα in the hypothalamus and the hippocampus is increased in aging and decreased in AD, while ERα is one of the regulators of AS and is subject to AS itself.
7 citations
7 citations
TL;DR: In this paper, the authors examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects.
7 citations
Book•
01 Jan 2006
TL;DR: Inflammatory, Oxidative and Vascular Factors Affecting Neuronal Cell Death in Alzheimer's Disease and its Potential Therapy with Neuroprotective Factors Synapse and Neuron Loss in Transgenic Mouse Models of Alzheimer's disease.
Abstract: Preface Inflammatory, Oxidative and Vascular Factors Affecting Neuronal Cell Death in Alzheimer's Disease Neuronal Cell Death in Alzheimer's Disease and its Potential Therapy with Neuroprotective Factors Synapse and Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease Neuropsychological Manifestations in Preclinical Alzheimer's Disease Altered Brain Activation During Cognitive Process in Alzheimer's Disease Premature Centromere Division (PCD) of the X Chromosome as a Bio Marker of the Brain Cells Re-entry into the Cell Division Cycle in Alzheimer's Disease The Aging Brain: The Risk Factor for Sporadic Alzheimer's Disease (SAD). Cellular and Molecular Aspects Remembering Emotional Information: Effects of Aging and Alzheimer's Disease APOE, Anxiety and Alzheimer's Disease Insulin Resistance, Depressive Disorders and Alzheimer's Disease Searching for Genetic Risk Factors in AD: A Never-Ending Story APOE and Cognitive Function in Non-demented Old Age: A Genetic Basis for Brain or Cognitive Reserve? Index.
7 citations
28 Dec 2016
7 citations