Topic
Aging brain
About: Aging brain is a research topic. Over the lifetime, 1255 publications have been published within this topic receiving 66405 citations.
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TL;DR: It is suggested that hippocampal function is preserved in normal aging and that repetition-based memory enhancing techniques may engage primarily neocortical attentional networks.
85 citations
TL;DR: It is suggested that fisetin supplementation may provide neuroprotection against aging‐induced oxidative stress, apoptotic cell death, neuro‐inflammation, and neurodegeneration in rat brain.
84 citations
TL;DR: A common signaling cascade now seems to link aging to age-associated pathologies of the brain, suggesting that pharmacologic approaches aimed at the modulation of this pathway can serve to delay the onset of age- associated disorders and improve the quality of life.
83 citations
TL;DR: Findings show that specific alterations occur in the activities of several mitochondrial enzymes in aging brain, including 3-hydroxybutyrate dehydrogenase, acetoacetyl CoA thiolase, and NAD-isocitrate dehydrogen enzyme.
Abstract: The effects of aging on the oxidation of labeled glucose and 3-hydroxybutyrate and on several mitochondrial enzymes in rat brain were investigated. The oxidation of labeled glucose and labeled 3-hydroxybutyrate was diminished by about 40 and 35%, respectively, in cerebral cortex slices from 2-year-old rats compared to those from 3-mo-old animals. A significant reduction in the activities of 3-hydroxybutyrate dehydrogenase, 3-oxo acid CoA transferase, acetoacetyl CoA thiolase, and NAD-isocitrate dehydrogenase was observed in brains of 1- and 2-year-old rats compared to 3-mo-old animals. However, aging had no effect on the activities of citrate synthase and pyruvate carboxylase. These findings show that specific alterations occur in the activities of several mitochondrial enzymes in aging brain.
83 citations
TL;DR: Findings indicate that of all examined measures, diffusion-based indices of white matter integrity may be the most sensitive indicators of global and regional declines and vascular damage in the aging brain.
83 citations