Topic
Aging brain
About: Aging brain is a research topic. Over the lifetime, 1255 publications have been published within this topic receiving 66405 citations.
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TL;DR: How glia are altered in the aging brain and whether these alterations are protective or contribute to the age-related pathological cascade are discussed.
53 citations
TL;DR: The results suggest that increased betaCTF99 expression is highly detrimental to the aging brain and that it produces a progressive and age-dependent AD-like pathogenesis.
53 citations
TL;DR: It is reported that countering age-related decreased O- GlcNAc transferase (OGT) expression and O-GlcNAcylation ameliorates cognitive impairments in aged mice and identifies O-glcNAcylaton as a key molecular mediator promoting cognitive rejuvenation.
53 citations
TL;DR: Melatonin has potential utility both in slowing normal brain aging and in treatment of neurodegenerative conditions, reinforced by the low cost of melatonin and its very low toxic hazard.
53 citations
TL;DR: The results showed improved cognitive performance and reorganized regional homogeneity of spontaneous fluctuations in the blood oxygen level-dependent signals in the superior and middle temporal gyri, and the posterior lobe of the cerebellum, in the participants who attended the intervention.
Abstract: Mounting evidence suggests that enriched mental, physical, and socially stimulating activities are beneficial for counteracting age-related decreases in brain function and cognition in older adults. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate the functional plasticity of brain activity in response to a combined cognitive-psychological-physical intervention and investigated the contribution of the intervention-related brain changes to individual performance in healthy older adults. The intervention was composed of a 6-week program of combined activities including cognitive training, Tai Chi exercise, and group counseling. The results showed improved cognitive performance and reorganized regional homogeneity of spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signals in the superior and middle temporal gyri, and the posterior lobe of the cerebellum, in the participants who attended the intervention. Intriguingly, the intervention-induced changes in the coherence of local spontaneous activity correlated with the improvements in individual cognitive performance. Taken together with our previous findings of enhanced resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe regions following a combined intervention program in older adults, we conclude that the functional plasticity of the aging brain is a rather complex process, and an effective cognitive-psychological-physical intervention is helpful for maintaining a healthy brain and comprehensive cognition during old age.
53 citations