Alcohol

About: Alcohol is a research topic. Over the lifetime, 22392 publications have been published within this topic receiving 295473 citations.

Liquid Phase Chlorination of Olefins with Cupric Chloride

Abstract: Cupric chloride reacts with gaseous and liquid olefins to form dichloroparaffins in various solvents under milder conditions. Acetic acid containing sodium acetate is the most convenient solvent for the reaction at lower temperatures. The reacting species in this system is found to be CuCl. OAc. NaCl. Acetonitrile containing lithium chloride and various alcohols can also be used as the solvent.Application of the reaction to butadiene in acetic acid containing sodium acetate has resulted in the formation of 1, 4-diacetoxy-2-butene and 3, 4-diacetoxy-1-butene.The kinetics of chlorination of styrene has been studied in acetonitrile-lithium chloride and in n-propyl alcohol. On the basis of the rate equation and the structure of the products, the chlorination mechanism and the retarding effect of cuprous chloride are discussed.

Ethanol oxidation by deermice mitochondria under physiologic conditions.

Abstract: Mitochondria obtained from alcohol dehydrogenase-positive or - negative deermice do not oxidize significant amounts of ethanol at pH 7.4. A slight activity, equivalent to less than 0.3% of the elimination rate in alcohol dehydrogenase-negative deermice was observed at pH 10; it was strongly inhibited by cyanide and thiourea, and was not dependent on exogenous NAD. Whereas ethanol oxidation by the cytosol of alcohol dehydrogenase-positive deermice was time-dependent, that of mitochondria from alcohol dehydrogenase-negative deermice was not. These findings indicate that deermice mitochondria do not oxidize ethanol at physiological pH, and that the mitochondrial system is not likely to play a significant physiologic role.

Method for production of optically active carboxylic acid ester

Abstract: Provided is a method for producing an optically active carboxylic acid ester at a high yield and with high enantioselectivity using dynamic kinetic resolution, said optically active carboxylic acid ester having an α-nitrogen substituent. This method for producing an optically active carboxylic acid ester includes a step in which racemic carboxylic acid represented by formula (a) and a specific alcohol or phenol derivative are reacted in a polar solvent having a dipole moment of at least 3.5 in the presence of an acid anhydride and an asymmetric catalyst, one enantiomer of the racemic carboxylic acid is selectively esterified, and the other enantiomer is racemized. In formula (a), Ra1 represents a nitrogen-containing heteroaromatic ring group bonded to an assymetric carbon via a nitrogen atom constituting a ring, and Ra2 is an organic group.

Method for the selective removal of acyl-functionality attached to the 2'-hydroxy-group of paclitaxel-related derivatives

Abstract: A method for removing acyl-groups appended by an ester linkage to the 2'-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2',7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions.