Topic
Aldehyde dehydrogenase
About: Aldehyde dehydrogenase is a research topic. Over the lifetime, 3365 publications have been published within this topic receiving 107683 citations.
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TL;DR: The role of ALDH in cancer and therapy resistance is discussed, and the various available ALDH inhibitors are overviewed with a focus on the clinical potential and limitations of these agents as cancer therapeutics.
56 citations
01 Jan 1978
TL;DR: The ontogenetic development of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenases (ALDH I and II) was followed in rats and the relative subcellular distribution of all enzymes was identical before birth, 7 days after birth and in adults.
Abstract: The ontogenetic development of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenases (ALDH I and II) was followed in rats. ADH could be detected just before birth and increased gradually to reach 82% of adult values at 47 days. ALDH I and II were present from day 15 of gestation, increased rapidly at birth, and reached 80-90% adult values at 47 days. The ratio between ALDH and ADH activities decreased gradually during ontogenesis. The relative subcellular distribution of all enzymes was identical before birth, 7 days after birth and in adults. The placental activities of ADH and ALDH I and II were studied at 15 and 20 days of pregnancy. ADH could not be detected in placentas. Low activities of ALDH I and II were present in placentas studied at 15 days of gestation, and still lower activities were found in placenta at 20 days.
55 citations
TL;DR: A novel 2-phenylethanol dehydrogenase has been purified from a soil bacterium Brevibacterium sp.
55 citations
TL;DR: In this paper, an acetaldehyde-derived DNA adduct, N 2 -ethylidene-2′-deoxyguanosine (N 2 -Eti-dG) was analyzed in stomach DNA of aldehyde dehydrogenase ( Aldh )- 2 -knockout mice that were fed with alcohol to determine effects of alcohol consumption and Aldh2 genotype on the level of DNA damage in stomach.
Abstract: We analyzed an acetaldehyde-derived DNA adduct, N 2 -ethylidene-2′-deoxyguanosine ( N 2 -Eti-dG) in stomach DNA of aldehyde dehydrogenase ( Aldh )- 2 -knockout mice that were fed with alcohol to determine effects of alcohol consumption and Aldh2 genotype on the level of DNA damage in stomach. Aldh2 -active(+/+), heterozygote(+/−) and knockout(−/−) mice were fed 20% ethanol for 5 weeks, then the level of N 2 -Eti-dG in stomach was determined by liquid chromatography tandem mass spectrometry. The average N 2 -Eti-dG level in DNA from untreated mice was not significantly different among Aldh2 genotypes (2.0–3.1 adducts/10 7 bases), however, the average N 2 -Eti-dG level in DNA from ethanol-treated mice was 4.8 ± 2.6 adducts/10 7 bases in Aldh2 +/+ mice, 7.9 ± 1.1 adducts/10 7 bases in Aldh2+ /− mice, and 48.6 ± 12.0 adducts/10 7 bases in Aldh2 −/− mice, respectively. Our data clearly showed that alcohol drinking caused DNA damage in stomach, which was Aldh2 genotype-dependent in this experimental animal model. This result suggests that heavy-alcohol drinking and Aldh2 deficiency might be risk factors of stomach cancer.
55 citations
TL;DR: The aldehyde dehydrogenase was specific for aliphatic aldehydes and required the presence of Fe2+ or Ca2+, and a flavin such as FAD or riboflavin, confirming that the aldealdehyde is an intermediate in the metabolic degradation of hydrocarbons by bacteria.
55 citations