Topic
Aldehyde dehydrogenase
About: Aldehyde dehydrogenase is a research topic. Over the lifetime, 3365 publications have been published within this topic receiving 107683 citations.
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TL;DR: It was proposed that overexpression of aldehyde dehydrogenase 6 could recover the yeast cell metabolism and hence increase ethanol production from lignocellulosic biomass containing furan-derived inhibitors.
70 citations
TL;DR: Great effects of the ALDH2 genotypes on alcohol sensitivity and alcohol-drinking behavior are found and it is shown that lymphocytes from habitual drinkers with the deficient AlDH2 enzyme had significantly higher frequencies of sister chromatid exchanges than those from AL DH2-proficient individuals.
Abstract: Excessive drinking of alcohol is now widely known to be one of the major lifestyle choices that ca effect health. Among the various effects of alcohol drinking, cytogenetic and other genotoxic effe...
70 citations
TL;DR: Results indicate that a direct effect of the Aldh2 genotype plays an important role on alcohol preference and acetaldehyde concentration in the brain is correlated with alcohol avoidance, and highlights the potential benefits of alcoholism and alcohol-related disease research in the animal model of ALDH2 alleles.
Abstract: Aldehyde dehydrogenase (ALDH) 2 plays a major role in the detoxification of aldehyde and is known to be responsible for alcohol preference. A diminished enzyme activity due to mutation of the Aldh2 gene is associated with high alcohol sensitivity and a low alcohol tolerance in humans. The genomic ba
70 citations
TL;DR: Measurements of oxygen consumption revealed that the electron transport system was capable of reoxidizing ALDH-generated NADH much faster than it was produced and hence was not rate-limiting for aldehyde metabolism.
70 citations
TL;DR: Parmacological activation of ALDH2 by Alda-1 reversed alcoholic steatosis and apoptosis through accelerating aldehyde clearance and indicates that AL DH2 is a promising molecular target and Alda -1 has therapeutic potential for treating alcoholic liver disease.
70 citations