Topic
Aldose
About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.
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TL;DR: The COOH-terminal domain of aldose reductase is crucial to the proper orientation of substrates in the active site and has become partially rate-limiting for the overall reaction.
77 citations
TL;DR: Results suggest AR2 is a vestigial NADPH-binding protein, perhaps similar in function to a number of non-mammalian crystallins which have been recruited into the lens, including peroxy-radical scavenging and recently discovered effects of metal ion chelation.
77 citations
77 citations
Patent•
04 Jun 1981
TL;DR: In this paper, the amine residues on polyglucosamine have been modified to form the groups: (a) --N═CHR or --NHCH 2 R (b) -- NHCH 2 CO 2 H (c) --NHHR" and (d) NHHR" where R is an aromatic moiety having at least one hydroxyl or carboxyl group, or a macrocyclic ligand R' is an aldose or ketose residue, and R" is an organometallic aldehyde residue.
Abstract: Derivatives have been formed from chitins and chitosans in which the amine residues on the polyglucosamine have been modified to form the groups: (a) --N═CHR or --NHCH 2 R (b) --NHR' (c) --NHR" and (d) --NH--CH 2 CO 2 H or --NH--glyceryl where R is an aromatic moiety having at least one hydroxyl or carboxyl group, or a macrocyclic ligand R' is an aldose or ketose residue, and, R" is an organometallic aldehyde residue These derivatives are useful in chelating metals, in pharmaceutical formulations, in cosmetics, in chromatographic separations, in enzyme immobilization, as catalysts, etc Galactomannans having selected amine-containing side chains have also been prepared by reductive amination
77 citations
TL;DR: Findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldosing reductases from the appropriate target tissue.
Abstract: The potency of the aldose reductase inhibitors 3,3-tetramethylene glutaric acid, 1, Alrestatin, 2, quercitrin, 3, T-hydroxy-4-oxo-4H-chromen-2-carboxylic acid, 4, its ethyl ester, 5, and 2-tetrazolyl-3-chloro-4-oxo-4H-chromen, 6, was evaluated against human placental aldose reductase prepared via affinity column chromatography. The order of potencies obtained was 4 >5 >2 >3 >1 > 6. This did not correlate with the order obtained against rat lens aldose reductase which was 3 >2 > 4 = 5 = 1=6. Except for 7-hydroxy-4-oxo-4H-chromen-2-carboxylic acid, 4, all compounds displayed decreased inhibition against human placental aldose reductase as compared to rat lens aldose reductase. These findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldose reductase.
77 citations