Topic
Aldose
About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.
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TL;DR: Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency, and structure-activity trends of the tested compounds are discussed.
Abstract: Various benzo[b]futran derivatives with a carboxymethylsulfamoyl group were prepared and evaluated for aldose reductase-inhibitory potency. Most of the compounds displayed significant inhibitory activities (IC50, 10-8-10-7M). Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency. Structure-activity trends of the tested compounds are discussed.
10 citations
TL;DR: In this article, a facile method was developed for the synthesis of 2-C-substituted 2-deoxy-D-glucoses using BF3-catalyzed cyclization between 1-alkenyl ethe...
Abstract: A facile method has been developed for the synthesis of 2-C-substituted 2-deoxy-D-glucoses and 2-C-disubstituted 2-deoxy-D-arabino-hexoses using the BF3-catalyzed cyclization between 1-alkenyl ethe...
10 citations
TL;DR: In this article, the vicinal diol system (12R,13S) present in 1 and 2 respectively has been transferred from the C-3, C-4 of diacetone glucose.
10 citations
10 citations
TL;DR: In this paper, the remaining unknown diastereoisomer of 5-hydroxymethyl-1,2,3,4,4-cyclohexanetetrol with the (1, 2, 3, 4, 5/0)-configuration has been synthesised as the pentaacetate from dl -(1 2/3, 4, 5, 5 )-triacetoxy-5-acetoxymethyl2-bromocyclohexane.
10 citations