Aldose

About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.

Heterocyclic compounds, their preparation and, pharmaceutical compositions containing them

Abstract: A heterocyclic compound selected from those of formula (1), tautomers thereof, and pharmaceutically acceptable salts and esters of formula (I) compounds and tautomers: wherein A represents an alkylene or alkenylene chain which has 1 to 4 carbon atoms and which may have a hetero atom; B, D and Y are selected independently from oxygen and sulfur atoms and NH; R' and R 2 are selected independently from hydrogen and halogen atoms and C, to C 5 alkyl, C, to C 5 alkoxy, C, to C 5 alkylthio, phenyl, nitro, hydroxyl, sulfo, imidazolyl-C 2 to C 5 acylamimo, amino and carboxyl groups; and R 3 represents a hydrogen atom, an amino group, a C 1 to C 5 alkyl group which may be substituted by a carboxyl group, or a phenyl group which may be substituted by a carboxyl, a carboxy-C 1 to C 5 alkyl, or an imidazolyl-C, to C 5 alkylamide group. These compounds, particularly when D is oxygen, are aldose reductose inhibitors useful in treatment of chronic diabetic complications.

Mild generation of alkylidenecarbenes from α-mesyloxynitriles of sugars. Application to the synthesis of branched-chain sugars

Abstract: Treatment of O-mesylcyanohydrins of furanos-3-ulose with sodium azide affords vinylazidoderivaties; the intermediary of an alkylidenecarbene is proposed, and reactions to trap such an intermediate are described.