Topic
Aldose
About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.
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TL;DR: In this paper, the first examples of steroidic C-glucosides, a new class of compounds useful as possible enzyme inhibitiors, were obtained by means of the 1HNMR spectra at 500 MHz or by chemical transformations.
4 citations
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06 Oct 1998TL;DR: In this paper, a method of manufacturing aldose or an aldoses derivative, with n carbon atoms, characterised by the fact than an aqueous solution of a salt of acid derivative of monosaccharide with n+2 carbon atoms containing at least one α-hydroxy acid unit, with the exception of gluconic acid, is brought into contact with hydrogen peroxide in the presence of at least 1 salt of a metal chosen from the group consisting of cobalt, nickel and ruthenium.
Abstract: The invention relates to a method of manufacturing an aldose or an aldose derivative, with n carbon atoms, characterised by the fact than an aqueous solution of a salt of acid derivative of monosaccharide with n+2 carbon atoms containing at least one α-hydroxy acid unit, with the exception of gluconic acid, is brought into contact with hydrogen peroxide in the presence of at least one salt of a metal chosen from the group consisting of cobalt, nickel and ruthenium.
4 citations
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4 citations
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31 Mar 1999
TL;DR: In this article, a new substituted indole alkanol acid (represented by the general formula I) interacting with an aldose reductase and suppressing the aldoses reactase was proposed.
Abstract: PROBLEM TO BE SOLVED: To provide a new effective and safe medicine for treating a diabetic composition. SOLUTION: The pharmaceutical composition includes a new substituted indole alkanol acid (represented by the general formula I) interacting with an aldose reductase and suppressing the aldose reactase. (Wherein, A is a 1-4C alkylene substituted with a 1-2C alkyl or a mono- or di-substituted with a halogen; z is a bond; R1 is H, a 1-6C alkyl or a halogen; R2 , R3 , R4 and R5 are each independently H, a halogen, nitro, a 1-6C alkyl, (substituted) benzyl or the like; R6 is H or a 1-6C alkyl).
3 citations
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TL;DR: This is the first tertiary structure of a mutant form of this AKR1B7 orthologue to be reported in order to investigate the structure-function relationship of the nonconserved His269 and its role in coenzyme binding.
Abstract: Rat aldose reductase-like protein (AKR1B14) is an orthologue of mouse vas deferens protein (AKR1B7) and plays roles in the detoxification of reactive aldehydes and synthesis of prostaglandin F2α. Here, the 1.87 A resolution crystal structure of the His269Arg mutant of AKR1B14 complexed with NADPH is described and shows that the negatively charged 2′-phosphate group of the coenzyme forms an ionic interaction with the positively charged guanidinium group of Arg269 that is also observed in the human aldose reductase (AKR1B1) structure. Previous experiments on the site-directed mutagenesis of His269 to Arg, Phe and Met revealed fourfold, sevenfold and 127-fold increases in the K m for NADPH, respectively, which are in agreement with the present molecular-modelling and X-ray crystallographic studies. This is the first tertiary structure of a mutant form of this AKR1B7 orthologue to be reported in order to investigate the structure–function relationship of the nonconserved His269 and its role in coenzyme binding.
3 citations