Aldose

About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.

Process for the preparation with a high concentration in hydrogen fluoride of branched oligo- and poly- osides particularly from saccharose

Abstract: The preparation process comprises the reaction of a glucide having at least one ketose pattern, such as saccharose, with hydrogen fluoride used as solvent and reactant, and thereafter the elimination of the hydrogen fluoride. The weight ratio between the glucide and hydrogen fluoride quantities is at least equal to two. The polymerisation degree of the products obtained is increased by using a mixture of said glucide with an aldose or polyaldocide. Application particularly to the preparation of food products susceptible of having a low caloric value, as well as products for cosmetology.

Discovery of New Inhibitors of Aldose Reductase from Molecular Docking and Database Screening.

Abstract: Aldose reductase (ALR2) is a target enzyme for the treatment of diabetic complications. Owing to the limited number of currently available drugs for the treatment of diabetic complications, the discovery of new inhibitors of ALR2 that can potentially be optimized as drugs appears highly desirable. In this study, a molecular docking analysis of the structures of more than 127,000 organic compounds contained in the National Cancer Institute database was performed to find and score molecules that are com- plementary to ALR2. Besides retrieving several carboxylic acid derivatives, which are known to generally inhibit aldose reductase, docking proposed other families of putative inhibitors such as sulfonic acids, nitro-derivatives, sulfonamides and carbonyl deriva- tives. Twenty-five compounds, chosen as the highest-scoring representatives of each of these families, were tested as aldose reduc- tase inhibitors. Five of them were found to inhibit aldose reductase in the micromolar range. For these active compounds, selectivity with respect to the closely-related aldehyde reductase was determined by measuring the corresponding inhibitory activ- ities. The structures of the complexes between the new lead inhibitors and aldose reductase, here refined with molecular mechanics and molecular dynamics calculations, suggest that new pharmacophoric groups can bind aldose reductase very efficiently. In the case of the family of the nitro-derivative inhibitors, a class of particularly interesting compounds, a round of optimizations was performed with the synthesis and biological evaluation of a series of derivatives aimed at testing the proposed binding mode and at improving interaction with active site residues. Starting from a hit compound having an IC50 of 42mM, the most potent compound synthesized showed a 10-fold increase in inhibitory activity and 10-fold selectivity with respect to ALR1, and structure-activity relationships of the designed compounds were in agreement with the proposed mode of binding at the active site. # 2002 Elsevier Science Ltd. All rights reserved.

Method for preparing 5-hydroxymethylfurfural from ketose sugars obtained by isomerisation of aldose sugars

Abstract: A method for preparing ketose sugars, characterised in that: 1/ at least one aldose sugar or a solution or a suspension of said sugar in water is solubilised, in at least one organic solvent; 2/ the organic solution obtained is brought into contact with a catalyst, in order to convert the aldose into ketose by means of an isomerisation reaction; 3/ then, optionally, the sugar solution obtained is dried; 4/ and finally, optionally, the isomerisation catalyst is removed by filtration.