Topic
Aldose
About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.
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Patent•
19 May 2004
TL;DR: An α-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecuse, which is a reducing end of an oligosaccharide with two or more monosac-charide residues connected by glycosidic linkages was described in this article.
Abstract: an α-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecuse, which is a monosaccharide or a reducing end of an oligosaccharide with two or more monosaccharide residues connected by glycosidic linkages (an oligosaccharide with two monosaccharide residues is disaccharide) (also referred to as “a disaccharide to an oligosaccharide”) or a sugar chain and alcoholic hydroxyl group of thiol group, to obtain a sugar structure glycoside containing α-glycoside at a high ratio, under the ring-shaped formation of a protective group in a silyl acetal structure over hydroxyl groups at positions 4 and 6 in the sugar structure. By the process, highly selective α-glycosylation of sugar structure can be progressed in a simple and efficient manner.
2 citations
2 citations
Patent•
30 Oct 1991
TL;DR: In this paper, the authors presented a compound which was obtained by reaction of the 9-hydroxyellipticine derivative of formula II with a halogenated sugar derivative in an organic solvent such as anhydrous methanol in the presence of a strong base such as sodium hydroxide.
Abstract: PURPOSE: To obtain the subject novel compound which is useful as an anticancer agent with excellent utility because of its antitumor properties and improved solubility in water. CONSTITUTION: The compound of formula I (R 1 , R 2 are each aldose residue, aldohexouronic acid residue; X - is inorganic or organic anion; N + -R 2 bond is glycoside bond between the position-2-N atom and the position-1-C atom of sugar in ellipticine structure), for example, 2-α-L-arabinopyranosyl-9-[(5R)- methoxycarbonyl-β-D-xylopyranosyloxy] ellipticinium bromide. This compound is obtained by reaction of the 9-hydroxyellipticine derivative of formula II with a halogenated sugar derivative of formula: R 3 -Y (R 3 is acylated aldose where the H atoms of OH in individual sugars are substituted with 2 to 9 C acyl, or acylated deoxyaldose; Y is halogen) in an organic solvent such as anhydrous methanol in the presence of a strong base such as sodium hydroxide. COPYRIGHT: (C)1993,JPO&Japio
2 citations
Patent•
27 Jan 2014TL;DR: Aldose reductase-specific inhibitors are used to treat a pathophysiological state or symptoms thereof resulting from aldose reduction in a cytotoxic pathway using an aldehyde specific inhibitor as discussed by the authors.
Abstract: Certain embodiments are directed to methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway using an aldose reductase specific inhibitor.
2 citations
2 citations