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Aldose
About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.
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18 Jul 2001TL;DR: Salts of Co, Ni or Ru are used as catalysts in the preparation of aldoses and aldose derivatives by treatment of an aqueous solution of a salt of an acid derivative of an ose with H2O2 as discussed by the authors.
Abstract: of EP0908465Salts of Co, Ni or Ru are used as catalysts in the preparation of aldoses and aldose derivatives by treatment of an aqueous solution of a salt of an acid derivative of an ose with H2O2. Process for preparing an aldose (I) or an aldose derivative (II) with n C atoms comprises contacting an aqueous solution of a salt of an acid derivative of an ose (III) with n+2 C atoms and at least one alpha -hydroxyacid group, with the exception of gluconic acid, with H2O2 in the presence of at least one salt of a metal selected from Co, Ni and Ru. Use of salts of Ni, Co or Ru as catalysts in the conversion gives high yields of the desired aldose products and provides a viable route to large scale production of aldose products at reasonable cost.
TL;DR: An unprecedented version of the Biginelli reaction using an unprotected aldose as a biorenewable aldehyde component and 2-phenyl-1,3-oxazol-5-one as a novel active methylene building block with urea/thiourea is reported in this article.
Abstract: An unprecedented version of the Biginelli reaction using an unprotected aldose as a biorenewable aldehyde component and 2-phenyl-1,3-oxazol-5-one as a novel active methylene building block with urea/thiourea is reported. The reaction is cerium(III)--catalyzed, expeditious, and effected under solvent-free microwave irradiation conditions to yield diastereoselectively, iminosugar-annulated polyfuntionalized perhydropyrimidines via ring transformation of an isolable intermediate followed by cyclodehydration.
TL;DR: Mylthio-d-ribose-1-phosphate (MTR1P) isomerase (MtnA) as discussed by the authors catalyzes the reversible isomerization of the aldose MTR 1P into the ketose methylthio d-ribulose 1-phophosphate, which serves as a member of the methionine salvage pathway.
Abstract: Methylthio-d-ribose-1-phosphate (MTR1P) isomerase (MtnA) catalyzes the reversible isomerization of the aldose MTR1P into the ketose methylthio-d-ribulose 1-phosphate. It serves as a member of the methionine salvage pathway that many organisms require for recycling methylthio-d-adenosine, a byproduct of S-adenosylmethionine metabolism, back to methionine. MtnA is of mechanistic interest because unlike most other aldose-ketose isomerases, its substrate exists as an anomeric phosphate ester and therefore cannot equilibrate with a ring-opened aldehyde that is otherwise required to promote isomerization. To investigate the mechanism of MtnA, it is necessary to establish reliable methods for determining the concentration of MTR1P and to measure enzyme activity in a continuous assay. This chapter describes several such protocols needed to perform steady-state kinetics measurements. It additionally outlines the preparation of [32P]MTR1P, its use in radioactively labeling the enzyme, and the characterization of the resulting phosphoryl adduct.