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Aldose

About: Aldose is a research topic. Over the lifetime, 1270 publications have been published within this topic receiving 27197 citations. The topic is also known as: aldoses.


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Journal ArticleDOI
TL;DR: It is proposed that interactions of inhibitors with the carboxy-terminal loop of aldose reductase are critical for the development of inhibitors that are able to discriminate between aldoses reductases and other members of the aldo-keto reduct enzyme superfamily.
Abstract: It is generally expected that only one inhibitor molecule will bind to an enzyme active site. In fact, specific drug design theories depend upon this assumption. Here, we report the binding of two molecules of an inhibitor to the same active site which we observed in the 1.8 A resolution structure of the drug Alrestatin bound to a mutant of human aldose reductase. The two molecules of Alrestatin bind to the active site in a stacked arrangement (a double-decker). This stack positions the carboxylic acid of one drug molecule near the NADP+ cofactor at a previously determined anion binding site and the carboxylic acid of the second drug molecule near the carboxy-terminal tail of the enzyme. We propose that interactions of inhibitors with the carboxy-terminal loop of aldose reductase are critical for the development of inhibitors that are able to discriminate between aldose reductase and other members of the aldo-keto reductase superfamily. This finding suggests a new direction for the introduction of specificity to aldose reductase-targeted drugs.

49 citations

Journal ArticleDOI
TL;DR: The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldoses purified from human brain, liver, and red cells.
Abstract: The effect of aldose reductase inhibitors such as sorbinil, alrestatin, and quercitrin has been studied on the aldose reductase purified from human brain and lens, and aldehyde reductase I purified from human liver, and aldehyde reductase II purified from human brain, liver, and red cells. None of the aldose reductase inhibitors have been found to be specific for aldose reductase. Fifty micromolar sorbinil besides inhibiting aldose reductase, completely inhibits aldehyde reductase II from the brain, liver and red cells. Similarly, alrestatin and quercitrin also are potent inhibitors of aldehyde reductase I and aldehyde reductase II.

49 citations

Journal ArticleDOI
TL;DR: In this article, the ketones (+)-1 and (−)-1 were derived from furan and 1-cyanovinyl (1S)-camphanate, respectively.
Abstract: (1S, 4R, 5S, 6S)-5-exo, 6-exo-(Isopropylidenedioxy)-7-oxabicyclo[2.2.1]heptan-2-one ((−)-1) was transformed with high stereoselectivity to L-allose. Similarly, enantiomer (+)-1 was transformed into L-talose. The ketones (+)-1 and (−)-1 were derived from furan and 1-cyanovinyl (1S)-camphanate and 1-cyanovinyl (1R)-camphanate, respectively.

48 citations

Journal ArticleDOI
TL;DR: In this paper, the reactions of various hydroxyl groups with tosylchloride-dimethylaminopyridine system were investigated and direct syntheses of allyl, alkyl and glycosyl chlorides were described.

48 citations

Journal ArticleDOI
TL;DR: Dispiroketal formation as a new method for the selective protection of trans diequatorial vicinal diols in carbohydrate systems is reported in this article, where the authors show that it can be applied to a wide range of applications.

48 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20233
20226
20213
20207
20196
201813