Showing papers on "Alkylation published in 1979"
TL;DR: In this article, a general, rapid method is described for alkylation of phenols and alcohols to give ethers, for amides to give N-substituted amides, and for acids to give esters.
306 citations
TL;DR: The formamide acetals as mentioned in this paper have been used in two main categories of reactions, namely alkylation and formylation, and are used in the synthesis of esters from acids, ethers and thioethers from phenols and aromatic and heterocyclic thiols.
233 citations
TL;DR: Bromotrimethylsilane is highly selective for P-O silyldealkylation of mixed carboxylate-phosphonate alkyl esters and can be used to prepare trimethylsilyl amido-, alkynyl-, and iodoalkyl-ph phosphonates in good yield, thus making the corresponding phosphonic acids readily available via hydrolysis with neutral H2O.
Abstract: Bromotrimethylsilane is highly selective for P–O silyldealkylation of mixed carboxylate–phosphonate alkyl esters and can be used to prepare trimethylsilyl amido-, alkynyl-, and iodoalkyl-phosphonates in good yield, thus making the corresponding phosphonic acids readily available via hydrolysis with neutral H2O.
141 citations
TL;DR: In this paper, a new selective alkylation procedure was developed which converted polar hydroxyls into relatively non-polar ethers and esters, and has been successfully tested on a bituminous and sub-bituminous coal.
116 citations
98 citations
89 citations
65 citations
62 citations
Patent•
20 Nov 1979TL;DR: In this article, a process for the selective alkylation of substituted or unsubstituted benzene compounds with relatively long chain length alkylating agents to produce phenylalkanes having an improved yield of the 2-phenylkane isomer is described.
Abstract: A process for the selective alkylation of substituted or unsubstituted benzene compounds with relatively long chain length alkylating agents to produce phenylalkanes having an improved yield of the 2-phenylkane isomer. The reaction is carried out in the presence of crystalline zeolite catalysts characterized by channels or networks of pores having openings with a major dimension of 6-7 angstroms.
58 citations
55 citations
TL;DR: In this paper, active methylene compounds are selectively monoalkylated with alkyl halides in benzene using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a base.
Abstract: Active methylene compounds are selectively monoalkylated with alkyl halides in benzene using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a base. Selectivity of monoalkylation decreases when the reaction is carried out in a polar solvent. Ethyl acetoacetate is O-acylated with acyl halides in the presence of DBU in acetonitrile to give the (E)-enol esters stereoselectively.
TL;DR: In this paper, the acidification of allylic substrates (chlorides, acetates, formate, and formate) with diethyl malonate anion is catalysed by the iron complexes (η3-crotyl) Fe(CO) 2NO−Na+ with good regioselectivity.
TL;DR: Alkylation of dibutylstannylene complexes of 3,4,6-tri-O -benzyl- D -mannopyranose, methyl 6- O -trityl-α-D -mannopeyranoside and methyl α-D-mannopryanoside gives respectively β- D-mannophyranoide and 3-O-alkyl derivatives with high selectivity as discussed by the authors.
TL;DR: Pentamethylcyclopentadienyl halostannanes are accessible by alkylation of tin tetrachloride and organotrichlorostannes with organolithium compounds and by oxidative addition reactions with decamethylstannocene, whose synthesis was also described as discussed by the authors.
TL;DR: In this paper, the reaction of trimethylbromosilane with an ester bearing a P=O phosphoryl group was studied and it was shown that the equilibrium for the phosphonium salt formation lies well over towards the intermediate and so the intermediate can be observed directly.
TL;DR: In this paper, a study of the reaction characteristics indicates that the nature of the counter ion (Li or Mg) is the critical factor in the asymmetric synthesis of chiral N,N -disubstituted amides.
TL;DR: It was concluded that polymers, particularly double-stranded DNA, reacted slower than deoxyguanosine due to the properties of polymers in solution rather than the unavailability of reactive sites for alkylation.
TL;DR: The O-silylated dienolates of unsaturated ketones and esters can be alkylated using zinc bromide catalysis to give predominantly the γ-alkylated carbonyl compounds as discussed by the authors.
TL;DR: The extractive alkylation of 11 sulphonamide diuretics has been evaluated and the trimethyl derivative of acetazolamide formed has been determined by electron-capture gas chromatography down to 0.5 microgram/ml in a 0.1-ml serum sample.
TL;DR: In this paper, the application of ion cyclotron resonance spectroscopy to the study of organometallic reactions is described, and a method for the determination of metal-hydrogen, metal-carbon and metal-ligand bond dissociation energies and representative results are given.
Abstract: The application of ion cyclotron resonance spectroscopy to the study of organometallic reactions is described. Methodology is outlined for the determination of metal-hydrogen, metal-carbon and metal-ligand bond dissociation energies and representative results are given. These data are of fundamental importance in understanding the reactions of organic molecules at transition metal centers. Decarbonylation of aldehydes and dehydrogenation of alkanes are treated as examples of oxidative addition processes. Elimination of methane from hydrido methyl complexes exemplifies the study of reductive elimination reactions. Additional examples include studies of the acylation and alkylation of metal complexes, and the reactions of molecular hydrogen with several coordinatively unsaturated species.
TL;DR: In this article, the reactions of iodine with ate-complexes prepared from trialkylboranes and 2-thienyllithium or 1-methyl-2-pyrrolyllithium were found to give the corresponding 2-alkylthiophenes or 2-methyl 2 -alkyl pyrroles in good yields.
Abstract: The reactions of iodine with ate-complexes prepared from trialkylboranes and 2-thienyllithium or 1-methyl-2-pyrrolyllithium were found to give the corresponding 2-alkylthiophenes or 1-methyl-2-alkylpyrroles, respectively, in good yields
Patent•
07 Aug 1979
TL;DR: In this article, a liquid phase process for the alkylation of aromatic hydrocarbons, with olefin, e.g., ethylene, propylene, etc., in the presence of a polyfluorosulfonic acid catalyst is described.
Abstract: This invention relates to conversion processes which take place in the presence of solid acid catalysts, e.g., hydrocarbon conversion processes. More specifically, this invention relates to a liquid phase process for the alkylation of aromatic hydrocarbons, with olefin, e.g., ethylene, propylene, etc., in the presence of a polyfluorosulfonic acid catalyst.