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Alkylation

About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.


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Journal ArticleDOI
Yanling Liu1, Deju Shang1, Xin Zhou1, Xiaohua Liu1, Xiaoming Feng1 
TL;DR: An efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with alkylidene malonates has been developed by using a chiral N,N'-dioxide-Sc(OTf)(3) complex as the catalyst (see scheme).
Abstract: An efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with alkylidene malonates has been developed by using a chiral N,N'-dioxide-Sc(OTf)(3) complex as the catalyst (see scheme). Some optically active intermediates containing the indole skeleton have been synthesized, such as indolepropionic acid, tryptamines, and beta-carbolines. The coordination between the scandium atom and the chiral N,N'-dioxide compound has been revealed by X-ray structure analysis.

111 citations

Journal ArticleDOI
TL;DR: In this article, the catalytic activity and properties peculiar to zeolite Y in various cationic and decationized forms during the alkylation reaction of toluene with methanol were investigated.

111 citations

Journal ArticleDOI
TL;DR: DFT calculations in the gas phase and in water bulk on the binol and benzo quaternary ammonium salts 2 and 4 evidence structural and electrostatic features of the binl derivative which might offer a rationalization of its promising high photo-cross-linking efficiency.
Abstract: The photogeneration and detection of new binol quinone methides undergoing mono- and bisalkylation of free nucleophiles was investigated by product distribution analysis and laser flash photolysis in water solution using binol quaternary ammonium derivatives 2 and 12 as photoactivated precursors. The alkylation processes of N and S nucleophiles are strongly competitive with the hydration reaction. DNA cross-linking potency of the water-soluble binol quaternary ammonium salt 2 was investigated as a pH function and compared to that of other quaternary ammonium salts capable of benzo-QM (QM = quinone methide) photogeneration by gel electrophoresis. DFT calculations in the gas phase and in water bulk on the binol and benzo quaternary ammonium salts 2 and 4 evidence structural and electrostatic features of the binol derivative which might offer a rationalization of its promising high photo-cross-linking efficiency.

111 citations

Journal ArticleDOI
TL;DR: Tungsten complex with a coordinated 2-azidoethyl isocyanide ligand reacts with PMe3 at the azido function to give a complex withA coordinated iminophosphorane which upon hydrolysis of the P=N bond yields acomplex with an NH,NH-stabilized N-heterocyclic carbene ligand.

111 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023652
20221,161
2021561
2020516
2019630
2018631