Topic
Alkylation
About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.
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Patent•
06 Mar 1996TL;DR: In this article, improved processes for the synthesis of 2'-Osubstituted pyrimidine nucleosides and oligomeric compounds having these nucleoside are disclosed.
Abstract: Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides and oligomeric compounds having these nucleosides are disclosed. The synthetic processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
107 citations
TL;DR: A novel a-alkylation reaction of imines is disclosed, which can be achieved by photoredox-mediated direct intermolecular C H functionalization of enamide derivatives, involving a radical/cationic domino process.
Abstract: Key features of the approach are the wide substance scope, short reaction times, high atom-economy (no side products) and good to excellent chemical yields.
107 citations
TL;DR: The LMCT excitation event has been investigated through a series of spectroscopic experiments, revealing a rapid bond homolysis process and an effective produc-tion of alkoxy radicals, collectively ruling out the LMCT/homolysis event as the rate determining step of this C-H functionalization.
Abstract: Modern photoredox catalysis has traditionally relied upon metal-to-ligand charge-transfer (MLCT) excitation of metal polypyridyl complexes for the utilization of light energy for the activation of organic substrates. Here, we demonstrate the catalytic application of ligand-to-metal charge-transfer (LMCT) excitation of cerium alkoxide complexes for the facile activation of alkanes utilizing abundant and inexpensive cerium trichloride as the catalyst. As demonstrated by cerium-catalyzed C-H amination and the alkylation of hydrocarbons, this reaction manifold has enabled the facile use of abundant alcohols as practical and selective hydrogen atom transfer (HAT) agents via the direct access of energetically challenging alkoxy radicals. Furthermore, the LMCT excitation event has been investigated through a series of spectroscopic experiments, revealing a rapid bond homolysis process and an effective production of alkoxy radicals, collectively ruling out the LMCT/homolysis event as the rate-determining step of this C-H functionalization.
107 citations
TL;DR: In this paper, a FeCl3-catalyzed alkylation of various active methylene compounds with various benzylic or allylic alcohols under mild conditions has been developed.
107 citations
Patent•
20 Mar 2007TL;DR: In this article, a process for the production of high quality gasoline blending components from refinery process streams by the alkylation of light isoparaffins with olefins using an ionic liquid catalyst is disclosed.
Abstract: A process for the production of a high quality gasoline blending components from refinery process streams by the alkylation of light isoparaffins with olefins using an ionic liquid catalyst is disclosed. The alkylation process comprises contacting a hydrocarbon mixture comprising at least one olefin having from 2 to 6 carbon atoms and at least one isoparaffin having from 3 to 6 carbon atoms under alkylation conditions, said catalyst comprising a mixture of at least one acidic ionic liquid and at least one alkyl halide. The alkylhalide by reacting to at least a portion of the olefin with a hydrogen halide.
107 citations