Topic
Alkylation
About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.
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91 citations
TL;DR: [Ir(COD)Cl]2/phosphoramidite ligand 1a was found to be an efficient catalytic system for the highly regio- and enantioselective decarboxylative alkylation of gamma-substituted allyl beta-ketocarboxyates, affording the branched products with up to >99/1 brancher-linear ratio and 96% ee.
91 citations
TL;DR: The solid phase synthesis of 3,4 disubstituted-7-carbamoyl-1,2,3,4-tetrahydroquinoxalin-2-ones 8 is described in this article, where 4-fluoro-3-nitrobenzoic acid is tethered to a solid support via the acid group.
Abstract: The solid phase synthesis of 3,4-disubstituted-7-carbamoyl-1,2,3,4-tetrahydroquinoxalin-2-ones 8 is described. 4-Fluoro-3-nitrobenzoic acid is tethered to a solid support via the acid group. Aromatic substitution of the resin-bound aryl fluoride with an α-amino ester is carried out in the presence of DIEA in DMF. The reduction of the aryl nitro group with SnCl2·H2O and subsequent intramolecular cyclization result in the formation of the core quinoxalinone. Selective alkylation at the N-4 position of the quinoxalinone is accomplished with alkyl halides in the presence of K2CO3. The desired products are cleaved from solid supports and obtained in from 32 to 93% isolated yields.
91 citations
TL;DR: A metal-catalyzed methylation process has been developed by employing an air- and moisture-stable manganese catalyst together with isotopically labeled methanol and a series of D-, CD3 -, and 13 C-labeled products were obtained in good yields under mild reaction conditions with water as the only byproduct.
Abstract: A metal-catalyzed methylation process has been developed. By employing an air- and moisture-stable manganese catalyst together with isotopically labeled methanol, a series of D-, CD3 -, and 13 C-labeled products were obtained in good yields under mild reaction conditions with water as the only byproduct.
91 citations
TL;DR: In this article, the naphthalene anion in tetrahydrofuran added negative charges to form the corresponding coal anions, and the alkylated coals were 88 and 45% soluble in benzene.
91 citations