Topic
Alkylation
About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.
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TL;DR: The use of a terpyridine ligand is essential for the success of the reaction and is shown to prevent photoinduced copper-catalyzed polymerization of the starting materials.
Abstract: We have developed a photoinduced copper-catalyzed alkylation of terminal alkynes with primary, secondary, or tertiary alkyl iodides as electrophiles. The reaction has a broad substrate scope and can be successfully performed in the presence of ester, nitrile, aryl halide, ketone, sulfonamide, epoxide, alcohol, and amide functional groups. The alkylation is promoted by blue light (λ≈450 nm) and proceeds at room temperature in the absence of any additional metal catalysts. The use of a terpyridine ligand is essential for the success of the reaction and is shown to prevent photoinduced copper-catalyzed polymerization of the starting materials.
87 citations
TL;DR: In this article, high yield dealkylation of several aryl methyl ethers was observed upon exposure of these compounds to an excess of the boron trihalide-methyl sulfide complexes.
87 citations
87 citations
TL;DR: Water-soluble, core-modified porphyrins were prepared and evaluated as sensitizers for photodynamic therapy (PDT) and distribution studies show that sensitizer 8 accumulates in the tumors of BALB/c mice.
Abstract: Water-soluble, core-modified porphyrins were prepared and evaluated as sensitizers for photodynamic therapy (PDT). The addition of an aromatic aldehyde to 2,5-dilithiothiophene or -selenophene gave diol 3 as a nearly equimolar mixture of meso and d,l diastereomers, which gave a single diastereomer following careful recrystallization. The condensation of pyrrole with a diol 3 using catalytic BF3-etherate gave bispyrrolochalcogenophenes (4). Condensation of a diol 3 with 4 in the presence BF3-etherate gave 21,23-dichalcogenaporphyrins (5). 21-Thiaporphyrins (6) were prepared by condensation of a diol 3 with excess pyrrole and benzaldehyde in the presence of tetrachlorobenzoquinone and catalytic BF3-etherate. Sulfonation of 5 and 6 with concentrated sulfuric acid at 100 °C gave sulfonated derivatives 7−15. Bis-4-methoxy-21,23-dithiaporphyrins 5h and 5l were demethylated with BBr3, and the resulting phenols were alkylated with ethyl bromoacetate. Saponification gave 21,23-dithiaporphyrin dicarboxylate salts 1...
87 citations
TL;DR: In this article, a number of medium- and large-pore zeolites (BEA, MOR, MAZ, FAU, LTL, OFF, and MTW) were considered and for each of them the minimum energy pathways for the diffusion of naphthalene, 1- and 2-methylnapthalene (MNs), and 1, 5-, 1, 6-, 2,6-, and 2,7-dimethylnapthylene (DMNs) were computed.
87 citations