Topic
Alkylation
About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.
Papers published on a yearly basis
Papers
More filters
TL;DR: In this paper, N-Acetanilid (I, II, III, IV, V, VI, VII, VIII, IX, and IX) in MeCN bei Gegenwart von Pd(OAc)2 nach Verfahren A.
Abstract: Durch Reaktion von N-Acetanilid (I) oder der substituierten N-Acetanilide (IV) bzw. (VI) mit Methyliodid (IIa) bzw. Ethyliodid (IIb) in MeCN bei Gegenwart von Pd(OAc)2 nach Verfahren A) werden die o-Alkylderivate (III), (V) bzw. (VII) erhalten.
239 citations
TL;DR: A novel catalytic hydrogen-autotransfer protocol for the atom-efficient α-alkylation of ketones with readily available alcohols and Mechanistic investigations suggest the participation of an intramolecular amidate-assisted alcohol-dehydrogenation process.
Abstract: A novel catalytic hydrogen-autotransfer protocol for the atom-efficient α-alkylation of ketones with readily available alcohols is presented The use of manganese complexes bearing non-innocent PNP pincer ligands enabled the functionalization of a broad range of valuable ketones, including 2-oxindole, estrone 3-methyl ether, and testosterone Mechanistic investigations suggest the participation of an intramolecular amidate-assisted alcohol-dehydrogenation process
238 citations
TL;DR: The first highly enantioselective catalytic reaction involving aromatic C-H bond activation is communicated and the identified catalyst system enables the intramolecular alkylation reaction to be performed at temperatures 75 degrees C lower than the previously reported achiral system.
Abstract: The first highly enantioselective catalytic reaction involving aromatic C−H bond activation is communicated. Enantioselective cyclization of aromatic ketimines containing alkenyl groups tethered at the meta position of an imine directing group has been achieved using 5 mol % [RhCl(coe)2]2 and 15 mol % of an (S)-binol-derived phosphoramidite ligand. Selectivities of up to 96% ee and up to quantitative yields were obtained. Moreover, the identified catalyst system enables the intramolecular alkylation reaction to be performed at temperatures 75 °C lower than our previously reported achiral system. The reaction can even be performed at room temperature for one of the optimal substrates.
237 citations
TL;DR: The activity of the cationic monoalkyls in catalytic ethene polymerization was found to vary by over 2 orders of magnitude depending on the metal ionic radius, the intermediate metal sizes being found to be the most effective.
Abstract: Using a sterically demanding amidinate ancillary ligand and an in situ alkylation procedure, neutral mono(amidinate) dialkyl and cationic mono(amidinate) monoalkyl complexes were prepared for metals spanning the full size range of the group 3 and lanthanide metals. The activity of the cationic monoalkyls in catalytic ethene polymerization was found to vary by over 2 orders of magnitude depending on the metal ionic radius, the intermediate metal sizes being found to be the most effective.
236 citations
TL;DR: The Pd-catalyzed reorganization of enol allyl carbonates to allylated ketones occurs asymmetrically in the presence of chiral ligands previously developed in this group, and for the first time, asymmetric creation of tertiary centers occurs with high ee.
Abstract: The Pd-catalyzed reorganization of enol allyl carbonates to allylated ketones occurs asymmetrically in the presence of chiral ligands previously developed in this group. With 2-methylcyclohexanone,...
235 citations