Topic
Alkylation
About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.
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TL;DR: The reaction of 2-(1-naphthyl)-3-methylpyridine with olefins in the presence of [RhCl(coe)2]2 and PCy3 as the catalyst resulted in the alkylation of the 2-position in good yield as discussed by the authors.
Abstract: The reaction of 2-(1-naphthyl)-3-methylpyridine with olefins in the presence of [RhCl(coe)2]2 and PCy3 as the catalyst resulted in the alkylation of the naphthyl ring at the 2-position in good yield. The replacement of PCy3 with the chiral ferrocenyl phosphine, (R),(S)-PPFOMe, as the ligand resulted in atropselective alkylation of the naphthylpyridine derivatives. Ethylene reacted with the biaryl compounds to give the corresponding addition products in moderate yields with fair to good ee's (up to 49% ee).
171 citations
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TL;DR: Homologous series of alkyl phosphonic acids andAlkyl sulfonic acids, along with inorganic orthophosphate and sulfate, have been identified in water extracts of the Murchison meteorite after conversion to their t-butyl dimethylsilyl (tBDMS) derivatives.
171 citations
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TL;DR: In this paper, the shape-selectivity of naphthalene and 2-methylnaphthalenes was investigated over H-mordenite (HM), HY and H-ZSM-5.
171 citations
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TL;DR: It is found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce ary lkyl ketones.
Abstract: We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones. The mild and transition-metal-free reaction conditions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. A reaction pathway involving single electron transfer from an enolate form of Breslow intermediate to a redox ester followed by recombination of the resultant radical pair to form a carbon–carbon bond is proposed.
170 citations
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TL;DR: In this article, a review examines some typical examples that illustrate the significant developments reported recently, in which external chiral ligands have been used as asymmetric controllers in stoichiometric and catalytic amounts.
Abstract: This review examines some typical examples that illustrate the significant developments reported recently, in which external chiral ligands have been used as asymmetric controllers in stoichiometric and catalytic amounts
169 citations