Alkylation

About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.

Design and reactivity of topologically unique, chiral phosphonamides. Remarkable diastereofacial selectivity in asymmetric olefination and alkylation

Abstract: On prepare des phosphonamides derivees du benzodiazaphosphole et on effectue l'olefination asymetrique de plusieurs cyclohexanones substituees

C-2/c-3 annulation and C-2 alkylation of indoles with 2-alkoxycyclopropanoate esters.

Abstract: The annulation reaction between various indoles and 2-alkoxycyclopropanoate esters is reported. Both high efficiency and complete stereochemical control were observed in some cases with this annulation process. A single stereocenter on the cyclopropane controls the diastereoselective formation of up to four new stereocenters. A different reaction course was observed with 3-substituted indole substrates, and an intervening C-3 to C-2-migration process arose that gives synthetically useful C-2 alkylation indole products.

Graphene-Catalyzed Direct Friedel-Crafts Alkylation Reactions: Mechanism, Selectivity, and Synthetic Utility.

Abstract: Transition-metal-catalyzed alkylation reactions of arenes have become a central transformation in organic synthesis. Herein, we report the first general strategy for alkylation of arenes with styrenes and alcohols catalyzed by carbon-based materials, exploiting the unique property of graphenes to produce valuable diarylalkane products in high yields and excellent regioselectivity. The protocol is characterized by a wide substrate scope and excellent functional group tolerance. Notably, this process constitutes the first general application of graphenes to promote direct C–C bond formation utilizing polar functional groups anchored on the GO surface, thus opening the door for an array of functional group alkylations using benign and readily available graphene materials. Mechanistic studies suggest that the reaction proceeds via a tandem catalysis mechanism in which both of the coupling partners are activated by interaction with the GO surface.

Participation of the α,α‘-Diiminopyridine Ligand System in Reduction of the Metal Center during Alkylation

Abstract: The reaction of {[2,6-(i-Pr)2PhNC(Me)]2(C5H3N)}MnCl2 with alkylating agents formed a dinuclear Mn(I) derivative via ligand reductive coupling. In the case of the trivalent Cr analogue, a similar reaction afforded reduction toward Cr(II) but also alkylation at the pyridine ring para position followed by an unprecedented cycloaddition that generated a tricyclic system.