Topic
Alkylation
About: Alkylation is a research topic. Over the lifetime, 29915 publications have been published within this topic receiving 464944 citations. The topic is also known as: alkylation reaction.
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136 citations
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TL;DR: In this paper, a simple FeCl2-catalyzed C-C bond formation by direct alkylation of activated methylene by using simple cycloalkanes was developed, and several kinds of alkanes were found to react with phenyl β-ketone ester and diketone compounds to afford alkylated 1,3-dicarbonyl compounds in 10-88% yields.
136 citations
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TL;DR: In this article, the first asymmetric catalytic alkylation of unmodified ketones with alkyl halides was reported, which requires light in order to proceed, providing a rare example of highly enantioselective photochemical catalytic processes.
Abstract: We report here the first asymmetric catalytic alkylation of unmodified ketones with alkyl halides. This metal-free approach, which requires light in order to proceed, provides a rare example of highly enantioselective photochemical catalytic processes. An easily available cinchona-based primary amine catalyst guides both the stereoselectivity-defining event and, through the transient formation of photon-absorbing chiral electron donor–acceptor complexes, the photo-activation of the substrates.
136 citations
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TL;DR: 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp3)–H and C(Sp2,–H) alkylation of simple amides with various alkyl iodides.
Abstract: 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp3)–H and C(sp2)–H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
136 citations
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TL;DR: A boron-based catalyst was found to catalyze the straightforward alkylation of amines with readily available carboxylic acids in the presence of silane as the reducing agent, successfully applied to the synthesis of three commercial medicinal compounds.
Abstract: A boron-based catalyst was found to catalyze the straightforward alkylation of amines with readily available carboxylic acids in the presence of silane as the reducing agent. Various types of primary and secondary amines can be smoothly alkylated with good selectivity and good functional-group compatibility. This metal-free amine alkylation was successfully applied to the synthesis of three commercial medicinal compounds, Butenafine, Cinacalcet. and Piribedil, in a one-pot manner without using any metal catalysts.
136 citations