Topic
Alveolar hydatid disease
About: Alveolar hydatid disease is a research topic. Over the lifetime, 171 publications have been published within this topic receiving 2993 citations. The topic is also known as: AHD & alveolar colloid of the liver.
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TL;DR: In this paper, first-time evidence was obtained about the phenomenon of natural resistance in non-diseased persons, which raised the question of a potential immunogenetic predisposition in certain infected persons.
Abstract: Echinococcus multilocularis, a small tapeworm in foxes, has gained considerable public attention owing to its wide distribution in central Europe. Conversely, diagnosis and treatment of the disease have been significantly improved in recent years. Consequently, the incidence among human populations has remained stable and relatively low for many decades. In southern Germany, France (Franche Comte and Doubs), Austria and Switzerland, the annual incidence ranges between 0.02 and 1.4 new cases per 100,000 inhabitants. The relevance of human AE refers to the high lethality of the untreated disease. Therapy consists predominantly of radical surgery followed by continuous, long-term chemotherapy using albendazole (or mebendazole). The action of chemotherapy alone is parasitostatic rather than parasitocidal; nevertheless, clinical improvement is observed in > 80 % of such cases, including a significantly improved prognosis. Diagnosis relies predominantly on imaging procedures and serology. Immunodiagnosis must be performed early, especially when a preclinical diagnosis is desired upon exposure to infection. Thus, in the framework of seroepidemiological studies, first-time evidence was obtained about the phenomenon of natural resistance in non-diseased persons. This raised the question of a potential immunogenetic predisposition in certain infected persons. E. granulosus (cystic hydatid disease) is practically non-existent as autochthonous infection in central Europe now. Most clinical cases of E. granulosus infections are thus observed among persons who have immigrated from - predominantly - the mediterranean basin.
15 citations
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TL;DR: This tapeworm’s life cycle, epidemiology, and pathophysiology in human disease is reviewed and the various modalities in diagnosis, treatment, and prevention are discussed.
Abstract: Summary Echinococcosis continues to be a serious public healthproblem throughout the world, especially in sheep-herding areas. Diagnosis should be suspected whenthere is a history of living in, or travel to, an endemicarea in the setting of a characteristic imaging study.Treatment should be tailored for each patient giventheir unique risks and benefits, but most should onlyreceive treatment if symptomatic. Through aggressivevaccination, education, and canine medication, oneday echinococcosis may be as out of date as hydatid isfor a “drop of water.”AcknowledgmentsWe thank Andrew Rhymer for the illustrations and James El-lzy for critical review of the manuscript.References 1. King C. Cestodes. In: Mandel G, Bennett J, Dolin R, edi-tors. Principles and practice of infectious diseases. 5th ed.Philadelphia, PA: Churchill Livingstone; 2000. Chap. 280.2. Moro PL, Gonzalez AE, Gilman RH. Cystic hydatid dis-ease. In: Strickland T, editor. Hunter’s tropical medicineand emerging infectious disease. 8th ed. Philadelphia,PA: WB Saunders; 2000. Chap. 124.2.3. Gilman RH, Lee BH. Alveolar hydatid disease. In: Strick-land T, editor. Hunter’s tropical medicine and emerginginfectious disease. 8th ed. Philadelphia, PA: WB Saun-ders; 2000. Chap. 124.3.4. Schantz PM. Polycystic hydatid disease. In: Strickland T,editor. Hunter’s tropical medicine and emerging infec-tious disease. 8th ed. Philadelphia, PA: WB Saunders;2000. Chap. 124.4.358 Infectious Diseases in Clinical Practice, Vol. 10, No. 7 Smith and Rickman
15 citations
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14 citations
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01 Jan 1989
TL;DR: The parasite epidemiology immunological aspects clinical echinococcosis the simple hepatic hydatid cyst the complicated hepatic Hydatid Cyst hydatod cyst of the lung hyd atid cysts at uncommon sites chemotherapy alveolar hydAtid disease.
Abstract: The parasite epidemiology immunological aspects clinical echinococcosis the simple hepatic hydatid cyst the complicated hepatic hydatid cyst hydatid cyst of the lung hydatid cysts at uncommon sites chemotherapy alveolar hydatid disease.
13 citations
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TL;DR: First-time evidence was obtained about the phenomenon of natural resistance in non-diseased persons as well as a potential immunogenetic predisposition in certain infected persons raised in the framework of seroepidemiological studies.
13 citations