Alveolar hydatid disease

About: Alveolar hydatid disease is a research topic. Over the lifetime, 171 publications have been published within this topic receiving 2993 citations. The topic is also known as: AHD & alveolar colloid of the liver.

Alveolar hydatid disease of the liver made by inoculation of scolices into the liver of cotton rat.

Abstract: 肝多包虫症の治療法の開発に役立つ実験モデルの作成を目的として,多包虫幼虫に感受性の高いCotton ratを用いて,腹腔内に継代移植している多包虫原頭節をサスペンジョンとして肝葉に接種した.肉眼的に接種8週後には5匹中4匹,10週後には4匹全例に肝に限局性のcystの形成を認めた.これは組織学的に完成した多包虫cystsであり,壁は2層よりなり,内面には繁殖胞が形成され,その内腔に多数の原頭節を認めた.この病巣は肝多包虫症の治療法の開発に有用と思われる.

Echinococcus multilocularis : Effect of Size of Inoculum and Route of Infection on Metastasis, Amyloidogenesis and Alveolar Hydatid Cyst Mass in Mice

Abstract: Alveolar hydatid disease (AHD) in mice, caused by Echinococcus multilocularis, is characterized by restrictive and metastasizing progressive growth phases. In experimentally induced infections, neither inoculum size (5, 50 or 250 viable cysts) nor the route (intraperitoneal/subcutaneous) of infection altered the course of disease as measured by the size of the larval cyst mass (LCM) produced. Spleen weight and amyloid deposition were also shown to be independent of the route or size of inoculum. Inoculation of a soluble parasite protein extract (AHC-EXT) induced amyloid deposition, with a dose-dependent threshold. These results support our postulate that soluble component(s) of the LCM are the major factor in the pathogenesis of AHD.

Clinical study of liver alveolar hydatid disease

Abstract: 113 patients with liver alveolar hydatid disease confirmed by laparotomy were analyzed. The patients were found in epidemic areas; this factor was considered in the diagnosis of the disease. Digestive tract symptoms and right epigastric mass, usually as firm as a stone, were the commonly seen clinical features. Many patients suffered from light anemia and hepatosis. Casoni test and PPA-ELISA were positive in 85.84% and 100% of the patients respectively. B-ultrasonography was most useful diagnostic means with characteristic wave shape and figure, and the diagnosis was confirmed by laparotomy in 93.18% of the patients. Most lesions were single large-well-circumscribed masses (53.93%); nodular lesions and mixed type lesions were found in 29.2% and 16.81% of the patients respectively. Radical resection was performed in 20 patients (17.7%), 85% of the patients were cured. Symptoms were relieved in 75% of the late-stage patients undergoing tumor excavation and drainage plus pharmacotherapy. Patients treated by albendazole, medicinal herbs, or both showed similar effective rates of 86.37%, 90%, and 88.23%, respectively (P greater than 0.05).

Echinococcus Alveolaris: Presenting as a Cerebral Metastasis Serebral Metastaz Şeklinde Ortaya Çikan Ekinokokus Alveolaris

Abstract: Echinococcus multilocularis (EM) is caused by the larval stage of the tapeworm. The main endemic regions for human alveolar echinococcosis are Central Europe, Russia, Turkey, Japan, China, Eastern France, North America. EM is an endemic disease in Turkey and especially common in the eastern Anatolia Region as seen in our case. The liver is the primary focus of the disease, cerebral localization is rare. Cerebral hydatid disease is approximately 5% of alveolar hydatid cases and generally considered to be fatal. Surgical treatment should be considerd whenever possible. We present a case of cerebral alveolar hydatid disease that was thought to be cerebral metastasis.

Historical Aspects of Hydatidosis of the Central Nervous System

Abstract: The aim of this study is to present the most important historical aspects of hydatidosis of the central nervous system. Echinococcosis or hydatidosis is a disease that has been recognized by humans for centuries. There has been mention of it in the studies of Hippocrates, Aretaeus, Galen and Rhazes. But, it was not until the seventeenth century that the parasitic nature of these cysts was recognized by Francesco Redi. In 1766 German Pierre Simon Pallas formulated the hypothesis that hydatid cysts were larval stages of tapeworms. Full understanding of the clinical features of this disease came in the late 1800s, which progressed to the development of immunological diagnostic tests by the early 1900s. Surgical techniques to remove cysts were first attempted in the 1600s, which has proven to be an effective treatment that is evolving with medical technology.