Topic
Ammonium tetrathiomolybdate
About: Ammonium tetrathiomolybdate is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 4249 citations.
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TL;DR: It was discovered that Cu(II)-treatments alone inhibited neoplastic growth and increased survival of rat and mouse models of cancer and another stable non-toxic and non-polar lipophilic chelate, Copper(II)2(3,5-ditertiarybutylsalicylate)4, was found to prevent Bax-initiated and caspases-3-activation mediated apoptosis.
Abstract: Co-Administration of Cu(II) chelates are reported to decrease life threatening Cisplatin [Pt(II) (NH3)2(CL)2]-induced acute degenerative renal, gastrointestinal, thymic, and bone marrow states consistent with serious necrotizing and immune-mediated inflammatory disease. Initially it was found that copper sulfate treatment completely prevented lethality as well as gastric and nephrotoxicity without compromising Pt(II) (NH3)2(CL) 2 antineoplastic activity, which led to suggestions that prior Cu(II)-treatment be used clinically to prevent serious side effects of Pt(II) (NH3)2(CL)2-treatment. In the course of these studies it was discovered that Cu(II)-treatments alone inhibited neoplastic growth and increased survival of rat and mouse models of cancer. Subsequently it was discovered that a stable non-toxic and non-polar lipophilic chelate, Copper(II)2(3,5-diisopropylsalicylate)4, caused redifferentiation of cultured neuroblastoma and mouse muscle-implanted mammary adenocarcinoma without neoplastic cell killing. Another stable non-toxic and non-polar lipophilic chelate, Copper(II)2(3,5-ditertiarybutylsalicylate)4, was found to prevent Bax-initiated and caspases-3-activation mediated apoptosis. These remarkable observations are concluded to be due to enzyme-mimetic or modulating reactivities of Cu(II) chelates and/or facilitation of Cu(II or I)-dependent enzyme syntheses required to overcome inflammatory-neoplastic disease states. Further, approaches to treating neoplastic diseases by removal of Cu from tissues with ammonium tetrathiomolybdate in an anticopper approach to therapy are not well founded based upon existing scientific literature.
21 citations
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TL;DR: Zn, which blocks absorption of Cu in the intestine by inducing intestinal cell metallothionein, and TM, which complexes Cu in a tripartite complex with protein, is used for the initial treatment of neurologically presenting patients.
20 citations
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TL;DR: In this paper, the catalytic performance of these catalysts in the hydrogenation of CO for the synthesis of higher alcohols along with catalyst characterization results were reported. But, the performance of the catalysts was not evaluated.
20 citations
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TL;DR: In this paper, an efficient HER electrochemical catalyst has been developed through an in-situ reduction of ammonium tetrathiomolybdate (ATTM) on carbon fibers (CFs) to afford layer-expanded MoS 2 /CFs composites.
20 citations
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TL;DR: The organic ammonium tetrathiomolybdates N-methylethylenediammonium (N-Me-enH2) (1), N-(3-aminopropyl)propane-1,3-diaminium-tetrathio-bdate (dipnH2)[MoS4] (2), 4-(2-ammonioethyl)piperazin-1-polyamide (PPA)-1-EtNH3) (3), 2,2′-imin
18 citations