Topic
Animal mortality
About: Animal mortality is a research topic. Over the lifetime, 526 publications have been published within this topic receiving 14887 citations.
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03 Mar 2021
TL;DR: Improved T1DM induction protocol which included single intaperitoneal injection of the streptozocin solution (60 mg/kg), 12 h fasting period prior to the procedure and prevention of the transient hypoglycemia by administration of 10% glucose solution is an effective method to induce T1 DM in adult male Wistar rats.
Abstract: Animal model of type 1 diabetes mellitus (T1DM) is a useful tool to test the efficacy of the modern medicines, study the course of surgical comorbidities and complications on the background of chronic hyperglycemia and pathology of the target organs. We aimed to improve streptozocin-induced T1DM protocol in adult male Wistar rats by combination of the approaches to decrease the toxic effect of the chemical agents, prevent hypoglycemia and, as a result, reduce the animal mortality rate. Adult male Wistar rats were divided into 2 groups: control — 20 animals and experimental — 20 animals. Protocol of steptozocin-induced T1DM (for both groups) consisted of the single intraperitoneal injection of the streptozocin solution (60 mg/kg). In order to prevent transitional hypoglycemia, animals (experimental group) were supplied with 10% Glucose solution or normal saline (control group) per os ad libitum for 24 h immediately after the injection. Glycaemia was measured by blood sugar monitor Accu Check (Roche, Germany). Blood sugar > 14 mmol/l was considered as the criterium of T1DM. Continuous monitoring of glycemia was used (48/96/168) to detect the risk of possible reversion. Hyperglycemia > 14 mmol/l was detected in 9% (19/20) of animals (experimental group) and 40% (8/20) control animals 48 h after induction; mortality rate was 5% and 55%, respectively. Reversion was identified in 2 rats of the experimental group 96 h after induction. Hence, improved T1DM induction protocol which included single intaperitoneal injection of the streptozocin solution (60 mg/kg), 12 h fasting period prior to the procedure and prevention of the transient hypoglycemia by administration of 10% glucose solution is an effective method to induce T1DM in adult male Wistar rats which induces clinically significant hyperglycemia (> 14 mmol/L). It is necessary to control blood glucose after T1DM confirmation in order to detect spontaneous reversion.
03 Jul 2011
Patent•
14 Jul 2017
TL;DR: The use of loganetin in preparation of drugs for prevention or treatment of arrhythmia belongs to the field of medicine as discussed by the authors, and the animal test results show that the loganeetin can significantly prevent and treat arrrhythmia, and can significantly delay the occurrence of premature ventricualr contraction, ventricular tachycardia and ventricular fibrillation of rats due to aconitine.
Abstract: The present invention relates to uses of loganetin in preparation of drugs for prevention or treatment of arrhythmia, and belongs to the field of medicine. According to the present invention, the loganetin is the tradition Chinese medicine monomer extracted from the traditional Chinese medicine; the animal test results show that the loganetin can significantly prevent and treat arrhythmia, can significantly delay the occurrence of premature ventricualr contraction, ventricular tachycardia and ventricular fibrillation of arrhythmia rats due to aconitine, can significantly reduce the animal mortality, and can significantly inhibit the ventricular fibrillation incidence rate of chloroform-induced arrhythmia mice; and the loganetin has advantages of exact arrhythmia treatment effect, low side effect, and broad medical application prospect.
01 Jan 2007
TL;DR: In this article, a study on six major highways of Lithuania in January-March 2003/2004 and 2004/2005 was carried out, where animal movement activity was documented following the footprints left on the snow.
Abstract: The research on wild hoofed animal vehicle collision was carried out on six major highways of Lithuania in January–March 2003/2004 and 2004/2005. In the highway environment, animal movement activity was documented following the footprints left on the snow. One-time account of hoofed animals was executed and the number of single animals of particular species crossing the highway at day and night in its separate sections was determined. The number of hoofed animals moving across different sections of highways differs significantly. The obtained findings are presented for the sections of a highway where the highest crossing activity was observed, i. e. in places potentially dangerous for local vehicle collision with wild animals. The highest activity of animals was determined on the Vilnius–Kaunas–Klaipėda highway (A1) at the 259 th –264 th km, with 7–10 animals per day/km. Roe deers cross the highway most often (up to 68%), wild boars are more rare (25%), red deer comprise 4% and elks up to 3%. The abundance of hoofed animals and movement intensity in winter depend on the size of forest massif (area), specific ecological conditions, on the habitat and other peculiarities of nature. In small grooves the possibility of vehicle and wild hoofed animal collision is less possible than in large massifs of forests. No statistical data have been published in Lithuania on the number of vehicle collision with wild animals, its seasonal dynamics, etc. Technical, biotechnical, traffic directing and other measures are suggested for reducing wild hoofed animal mortality rate and for decreasing the number of road accidents.
TL;DR: Indralin treatment after irradiation resulted in a 30% increase in survival of exposed mice, and eliminated phase I of acute GVH reaction and shifted to the right the dynamics of mortality.
Abstract: The effect of radioprotector indralin on the graft-versus-host reaction was studied on the model of acute GVH disease induced in mice by intraperitoneal transplantation of 40×106 semiallogenic splenocytes. The effect was evaluated by animal mortality from GVH disease. Recipients were male F1(CBA × C57Bl/6) mice exposed to 7 Gy 24 h before transplantation. Donors were male C57Bl/6 mice. Indralin, intraperitoneally injected in a dose of 100 mg/kg 5 min after irradiation attenuated the severity of GVH disease. It eliminated phase I of acute GVH reaction and shifted to the right the dynamics of mortality. Estimated time of 50% mortality (LT50) was prolonged by more than 4 days (the parameter increased by 31.1%). Two (5.7%) animals recovered from acute GVH disease, while all controls died. Indralin treatment after irradiation resulted in a 30% increase in survival of exposed mice.