Topic
Animal mortality
About: Animal mortality is a research topic. Over the lifetime, 526 publications have been published within this topic receiving 14887 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: This study revealed that the use of autologous whole blood (AWB) in the acute model employed was unable to reduce the parasitic load of infected mice, providing only a minor decrease in parasitemia levels but without protecting against animal mortality.
Abstract: Autologous whole blood (AWB) administration is described as alternative/complementary medical practice widely employed in medical and veterinary therapy against infections, chronic pathologies and neoplasias Our aim is to investigate in vivo biological effect of AWB using healthy murine models under the course of Trypanosoma cruzi acute infection The first set of studies consisted of injecting different volumes of AWB and saline (SAL) into the posterior region of quadriceps muscle of healthy male Swiss mice under distinct therapeutic schemes evaluating: animal behavior, body and organ weight, hemogram, plasmatic biochemical markers for tissue damage and inflammatory cytokine levels and profile To assess the impact on the experimental T cruzi infection, different schemes (prior and post infection) and periods of AWB administration (from one up to 10 days) were conducted, also employing heterologous whole blood (HWB) and evaluating plasma cytokine profile No major adverse events were observed in healthy AWB-treated mice, except gait impairment in animals that received three doses of 20 μL AWB in the same hind limb AWB and SAL triggered an immediate polymorphonuclear response followed by mononuclear infiltrate Although SAL triggered an inflammatory response, the kinetics and intensity of the histological profile and humoral mediator levels were different from AWB, the latter occurring earlier and more intensely with concomitant elevation of plasma IL-6 Inflammatory peak response of SAL, mainly composed of mononuclear cells with IL-10, was increased at 24 h According to the mouse model of acute T cruzi infection, only minor decreases (< 30%) in the parasitemia levels were produced by AWB and HWB given before and after infection, without protecting against mortality Rises in IFN-gamma, TNF-alpha and IL-6 were detected at 9 dpi in all infected animals as compared to uninfected mice but only Bz displayed a statistically significant diminution (p = 002) in TNF-alpha levels than infected and untreated mice This study revealed that the use of autologous whole blood (AWB) in the acute model employed was unable to reduce the parasitic load of infected mice, providing only a minor decrease in parasitemia levels (up to 30%) but without protecting against animal mortality Further in vivo studies will be necessary to elucidate the effective impact of this procedure
1 citations
Patent•
23 Mar 2016
TL;DR: In this paper, a pharmaceutic preparation for preventing and treating arrhythmia and application thereof is presented, which is prepared from common macrocarpium fruit, salviae miltiorrhizae, saffron, milkvetch roots, turmeric root tubers, rhizoma chuanxiong, common cephalanoplos herb, lotus seeds, Fructus arctii, alpine swertia, cinnamon, corn stigmas, fructus schizandrae, licorice roots, poly
Abstract: The invention relates to a pharmaceutic preparation for preventing and treating arrhythmia and application thereof. The pharmaceutic preparation is prepared from common macrocarpium fruit, salviae miltiorrhizae, saffron, milkvetch roots, turmeric root tubers, rhizoma chuanxiong, common cephalanoplos herb, lotus seeds, fructus arctii, alpine swertia, cinnamon, corn stigmas, fructus schizandrae, licorice roots, polygonumaviculareL., gold silkworms, pear peels, honeysuckle flowers, cape jasmine fruit, Huai wheat, immature bitter oranges and poria cocos. According to the prescription, materials are selected scientifically, the pharmaceutic preparation prepared through the preparation method has the prominent function of preventing or treating the arrhythmia, and the pharmaceutic preparation can prominently prolong the occurrence time of rat arrhythmia ventricular beat, ventricular tachycardia and ventricular fibrillation caused by aconitine and reduce animal mortality. By means of acute toxicity tests and long term toxicity tests, the toxic and side effects are low, the safety of drug use can be obviously improved, and the pharmaceutic preparation for preventing and treating the arrhythmia and the application thereof are suitable for further application and promotion in clinic.
1 citations
TL;DR: In this article, the economic feasibility of four alternative large animal mortality composting systems that a producer-owned entity could potentially operate was examined and the four systems evaluated are a vertical mechanical composter (Dutch Composter), a horizontal mechanical compener (BIOvator TM), an open static pile yard and a roofed or covered static pile yards.
Abstract: This study examines the economic feasibility of 4 alternative large animal mortality composting systems that a producer-owned entity could potentially operate The 4 systems evaluated are a vertical mechanical composter (Dutch Composter), a horizontal mechanical composter (BIOvator TM ), an open static pile yard and a roofed or covered static pile yard This study includes a 5-year pro forma financial analysis and suggests recommendations regarding the most economically viable and environmentally appropriate alternatives Based on the financial analysis and the current regulatory environment, the recommended compost system for a regional animal mortality facility is static piles under roof However, alternative technologies may be feasible in other scenarios
1 citations
15 Mar 2016
TL;DR: Results demonstrate 1373-mediated induction of, and host cell response to, both IFN-α and IFN–γ, and the potential forIFN-γ to be a predictive marker for mortality during BVDV infection.
Abstract: Bovine viral diarrhea virus (BVDV) is a pestivirus that suppresses the innate and adaptive host immune responses. Each of the two classified genotypes (BVDV1 and BVDV2) has two distinct biotypes – cytopathic (cp) and non-cytopathic (ncp) – and evidence has suggested that cytopathic strains may disrupt host interferon (IFN) synthesis and IFN-mediated responses. However, inconsistent results examining ncpBVDV strains have generated controversy regarding whether they also exhibit this capability. The purpose for this study was to determine the occurrence and functionality of IFN-induced responses within the serum cattle infected with ncpBVDV2-1373. Specifically, this involved analysing the changes in both the serum levels of IFN-α and IFN-γ and the expression of genes that are classically regulated by these cytokines. Serum analysis showed that the infected cattle induced both serum IFN-α and IFN-γ during BVDV infection while PBMC analysis showed increased expression of genes that classically respond to IFN-α – Mx-1, OAS-1, and STAT-1 – and IFN-γ – SOCS-1 and SOCS-3. These findings are supported by temporal kinome analysis, which verified activation of the JAK-STAT signalling network within the PBMCs of the virus-infected animals. In addition to establishing evidence for its synthesis, results from this challenge identified IFN-γ as a possible indicator of animal mortality as analysis of its change within the non-surviving, infected animals was statistically greater than the levels of the surviving, infected animals. Collectively, these results demonstrate 1373-mediated induction of, and host cell response to, both IFN-α and IFN–γ, and the potential for IFN-γ to be a predictive marker for mortality during BVDV infection.
1 citations
TL;DR: It was shown that implantation of the proposed CEC normalizes blood biochemical parameters and structural disorders of the damaged rat liver faster and has reduced animal mortality from 50 to 0%, which is due to early activation of proliferation of viable liver cells and faster formation of new blood vessels.
Abstract: Objective: to investigate the functional efficiency of a cell-engineered construct (CEC) of the liver based on tissuespecific matrix consisting of decellularized rat liver fragments, allogeneic liver cells and multipotent mesenchymal stromal cells (MSCs) isolated from the bone marrow on an experimental model of chronic liver failure (CLF). Materials and methods . In creating liver CECs, the liver for decellularization and liver cells were obtained from male Wistar rats. MSCs were isolated from rat bone marrow. The functional efficacy of CEC was investigated on an experimental CLF model obtained by priming rats with CCl 4 solution. At different periods after implantation, the outcomes were assessed based on the biochemical parameters of cytolysis. Morphological changes in the liver were analyzed by histochemical methods in the control (administration of saline solution into the liver parenchyma) and experimental (administration of liver CEC into the liver parenchyma) groups. Results . It was shown that implantation of the proposed CEC normalizes blood biochemical parameters and structural disorders of the damaged rat liver faster (by day 30 after introduction of CEC instead of day 180 in the control). The CEC was also shown to have reduced animal mortality from 50 to 0%, which is due to early activation of proliferation of viable liver cells and faster formation of new blood vessels. These effects are down to either stimulation of the internal regenerative potential of the damaged liver during CEC implantation or long-term functioning of the transplanted cells as part of the CEC based on the decellularized liver matrix. Conclusion. The liver CEC, implanted into the liver parenchyma in laboratory animals with a CLF model, has a functional activity.
1 citations