Topic
Annulation
About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.
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TL;DR: In this article, the synthesis of fused polycyclic quinolines can be viewed as occurring through a tandem concerted Diels-Alder/annulation reactions of β-(2-aminophenyl)-α, β-ynones with enamines, azides and nitrile oxides.
76 citations
TL;DR: Silica supported perchloric acid (HClO4-SiO2) was found to be a heterogeneous recyclable catalyst for the rapid and efficient synthesis of various poly-substituted quinolines in the Friedlander condensation of 2-aminoarylketones with carbonyl compounds and β-keto esters at ambient temperature as discussed by the authors.
Abstract: Silica supported perchloric acid (HClO4-SiO2) is found to be a heterogeneous recyclable catalyst for the rapid and efficient synthesis of various poly-substituted quinolines in the Friedlander condensation of 2-aminoarylketones with carbonyl compounds and β-keto esters at ambient temperature. The catalyst can be reused at least three times.
76 citations
TL;DR: In this paper, a palladium-catalyzed formal [4 + 1] annulation reaction was developed for the synthesis of a wide range of polycyclic aromatic hydrocarbons (PAHs) and 1H-indenes with easily available (trimethylsilyl)diazomethane as the carbene source.
Abstract: A highly efficient and operationally simple palladium-catalyzed formal [4 + 1] annulation reaction has been developed. The reaction is featured by the formation of two different C–C bonds on a carbenic center. It represents a concise method for the synthesis of a wide range of polycyclic aromatic hydrocarbons (PAHs) and 1H-indenes with easily available (trimethylsilyl)diazomethane as the carbene source. Metal carbene migratory insertion and C(sp2)–H bond activation are proposed as the key steps in this transformation. The reaction further demonstrates the versatility of the carbene-based coupling in combination with various transition-metal-catalyzed transformations.
75 citations
TL;DR: The Sc(OTf)3-catalyzed (3 + 2)-annulation of donor-acceptor cyclopropanes and ynamides is described, providing the corresponding cyclopentene sulfonamides in good to excellent yield.
75 citations
TL;DR: In this article, the authors targeted electrochemical annulation reactions involving mediators and mediator-free conditions with generation of new C-C, C-heteroatom and heteroatom heteroatoms, their mechanistic insights, as well as the reactivity of substrates.
75 citations