Topic
Annulation
About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.
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72 citations
TL;DR: This sequences allows for the asymmetric convergent union of two aldehydes with silyl-stannane reagent 1 in a two-step process: catalytic asymmetric allylation of the first aldehyde using 1 with a BITIP catalyst, followed by reaction of the alcohol so obtained with a second alde Hyde and TMSOTf.
72 citations
TL;DR: The reaction of alpha-aryl-substituted carbonyl compounds with terminal or internal alkynes in the presence of TiCl4 regioselectively generates substituted naphthalene derivatives in good to excellent yields.
Abstract: A new straightforward procedure has been developed for the synthesis of polysubstituted naphthalene derivatives. The reaction of α-aryl-substituted carbonyl compounds with terminal or internal alkynes in the presence of TiCl4 regioselectively generates substituted naphthalene derivatives in good to excellent yields.
72 citations
TL;DR: The functionalized FGH ring system of micrandilactone A was successfully constructed in high selectivity and good yields, and the key reactions in this strategy are the Co-thiourea-catalyzed stereoselective, intramolecular Pauson-Khand reaction and Pd-thio-catalystzed stereospecific annulation.
72 citations
TL;DR: This first example of using NHC organocatalysis in a double vinylogous Michael type reaction, a challenging but highly desirable topic, affords good yields as well as high to excellent diastereo- and enantioselectivities.
Abstract: A strategy for the N-heterocyclic carbene (NHC) catalyzed asymmetric synthesis of 3,5-diaryl substituted cyclohexenones has been developed via oxidative [4+2] annulation of enals and alkenylisoxazoles. It is the first example of using NHC organocatalysis in a double vinylogous Michael type reaction, a challenging but highly desirable topic. This unprecedented protocol affords good yields as well as high to excellent diastereo- and enantioselectivities.
72 citations