Topic
Annulation
About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The straightforward entry to benzofuroindoline containing natural product-like scaffolds has been achieved by a challenging [3 + 2] oxidative coupling between phenols and indoles.
61 citations
••
TL;DR: A copper-catalyzed reaction of arylacetylene or enyne with C(60)Ar(5)Br effects a formal [4 + 2] annulation reaction to form a dihydronaphthalene ring fused to the fullerene core and creates axial chirality in the product because of restricted rotation of the top aryal groups.
Abstract: A copper-catalyzed reaction of arylacetylene or enyne with C60Ar5Br effects a formal [4 + 2] annulation reaction to form a dihydronaphthalene ring fused to the fullerene core. The reaction involves a formal C−H bond activation and takes place by a copper-mediated radical mechanism. This reaction takes place in 60−75% overall yield from [60]fullerene and creates axial chirality in the product because of restricted rotation of the top aryl groups.
61 citations
••
61 citations
••
TL;DR: The N-heterocyclic carbene-catalyzed generation of dienoate from α,β-unsaturated carboxylic acid via the in situ formed mixed anhydride, and the following [4 + 2] annulation with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones and spirocyclic oxindolodihydropyrIDinones in moderate to good yields with good
Abstract: The N-heterocyclic carbene-catalyzed generation of dienoate from α,β-unsaturated carboxylic acid via the in situ formed mixed anhydride, and the following [4 + 2] annulation with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones and spirocyclic oxindolodihydropyridinones, respectively, in moderate to good yields with good to excellent enantioselectivities.
61 citations
••
TL;DR: Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope and a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence.
Abstract: 1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic–ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.
61 citations