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Annulation

About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.


Papers
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Journal ArticleDOI
TL;DR: The straightforward entry to benzofuroindoline containing natural product-like scaffolds has been achieved by a challenging [3 + 2] oxidative coupling between phenols and indoles.

61 citations

Journal ArticleDOI
TL;DR: A copper-catalyzed reaction of arylacetylene or enyne with C(60)Ar(5)Br effects a formal [4 + 2] annulation reaction to form a dihydronaphthalene ring fused to the fullerene core and creates axial chirality in the product because of restricted rotation of the top aryal groups.
Abstract: A copper-catalyzed reaction of arylacetylene or enyne with C60Ar5Br effects a formal [4 + 2] annulation reaction to form a dihydronaphthalene ring fused to the fullerene core. The reaction involves a formal C−H bond activation and takes place by a copper-mediated radical mechanism. This reaction takes place in 60−75% overall yield from [60]fullerene and creates axial chirality in the product because of restricted rotation of the top aryl groups.

61 citations

Journal ArticleDOI
TL;DR: The N-heterocyclic carbene-catalyzed generation of dienoate from α,β-unsaturated carboxylic acid via the in situ formed mixed anhydride, and the following [4 + 2] annulation with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones and spirocyclic oxindolodihydropyrIDinones in moderate to good yields with good
Abstract: The N-heterocyclic carbene-catalyzed generation of dienoate from α,β-unsaturated carboxylic acid via the in situ formed mixed anhydride, and the following [4 + 2] annulation with hydrazones and isatin-derived imines was developed, affording the corresponding dihydropyridinones and spirocyclic oxindolodihydropyridinones, respectively, in moderate to good yields with good to excellent enantioselectivities.

61 citations

Journal ArticleDOI
Hai Xu1, Jia He1, Jiarong Shi1, Liang Tan1, Dachuan Qiu1, Xiaohua Luo1, Yang Li1 
TL;DR: Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope and a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence.
Abstract: 1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic–ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.

61 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023468
2022850
2021754
2020618
2019699
2018603