Topic
Annulation
About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.
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TL;DR: An efficient three-component thieno[2,3-b]indole formation method was developed under metal-free conditions, which enabled modular synthesis of 2-substituted and 3-subStituted thienos with excellent regioselectivity and broad functional group tolerance.
60 citations
TL;DR: An efficient and highly selective approach for the synthesis of functionalized 4H-chromenes has been developed via gold(III)-catalyzed condensation/annulation tandem reaction of ketones with phenols.
Abstract: An efficient and highly selective approach for the synthesis of functionalized 4H-chromenes has been developed via gold(III)-catalyzed condensation/annulation tandem reaction of ketones with phenols.
60 citations
TL;DR: In this paper, a catalytic atroposelective cycloaddition reaction between thioureas and ynals was developed for axially chiral thiazine derivative products.
Abstract: A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This reaction features the first NHC-catalyzed addition of thioureas to acetylenic acylazolium intermediates to eventually set up C-N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups and are feasible for further transformations.
60 citations
TL;DR: A novel copper-mediated annulation of alkyl ketones with α,β-unsaturated carboxylic acids has been accomplished and provides a facile and regio-defined method for the synthesis of 2,3,5-trisubstituted furans from simple chemical reagents.
60 citations
TL;DR: In this article, a synthetic method for isoquinoline synthesis via a [4+2] annulation of NH imines with alkynes using the high-valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described.
Abstract: A synthetic method for isoquinoline synthesis via a [4+2] annulation of NH imines with alkynes using the high-valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described. Cerium(IV) sulfate was found to be an efficient oxidant in lieu of the commonly used copper or silver salts. Broad substrate scope, high functional group tolerance, and generally good yields were observed.
60 citations