Topic
Annulation
About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.
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TL;DR: A new cobalt(II)-catalyzed decarboxylative C-H activation/annulation of benzamides and alkynyl carboxylic acids has been described, which enables a switchable cyclization to isoquinolones and isoindolinones with excellent selectivity.
101 citations
100 citations
TL;DR: A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described, leading to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield.
Abstract: A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described. These studies have led to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield. Three approaches to the synthesis of ketone 2 are described that allow for its preparation in large quantities in >65% overall yield from methyl 6-methylnicotinate.
100 citations
100 citations
TL;DR: An efficient indole-to-carbazole strategy has been developed under metal-free conditions that conveniently enabled the assembly of a large number of diversified carbazole products with good tolerance of a broad range of functional groups.
100 citations