Topic
Annulation
About: Annulation is a research topic. Over the lifetime, 10152 publications have been published within this topic receiving 189701 citations.
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TL;DR: A novel asymmetric [4+1] annulation of MBH carbonates with dicyano-2-methylenebut-3-enoates has been developed for the first time, providing an efficient and enantioselective synthesis of highly functionalized cyclopentenes bearing one all-carbon quaternary stereogenic center.
90 citations
TL;DR: A Rh(III)-catalyzed intramolecular redox-neutral or oxidative annulation of a tethered alkyne has been developed to efficiently construct 3,4-fused indoles via a C-H activation pathway.
90 citations
TL;DR: The first example of (3+3)-annulation of two different three-membered rings is reported, applicable for the broad substrate scope and exhibits an excellent functional group tolerance.
Abstract: The first example of (3+3)-annulation of two different three-membered rings is reported herein. Donor-acceptor cyclopropanes in reaction with diaziridines were found to afford perhydropyridazine derivatives in high yields and diastereoselectivity under mild Lewis acid catalysis. The disclosed reaction is applicable for the broad substrate scope and exhibits an excellent functional group tolerance.
90 citations
90 citations
TL;DR: In this paper, the synthesis of polycyclic indoles is shown to be accomplished readily by the palladium catalyzed intramolecular cyclization of bromoaryl bearing indales.
90 citations