Topic
Anthrax vaccines
About: Anthrax vaccines is a research topic. Over the lifetime, 685 publications have been published within this topic receiving 21495 citations.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AigIV-treated animals and BioThrax (anthrax vaccine adsorbed) in rabbits.
Abstract: Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a component of anthrax toxins. We evaluated the interaction between AIGIV and BioThrax (anthrax vaccine adsorbed) in rabbits. While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AIGIV-treated animals.
16 citations
••
TL;DR: A culture-independent method of diagnosing anthrax through the use of monoclonal antibodies to detect PA and LF in the lethal toxin complex is demonstrated.
16 citations
••
TL;DR: It is suggested that antigen destabilisation is not a primary mechanism of Alhydrogel adjuvancy and informative structural characterisation is possible for adjuvant bound sub-unit vaccines.
16 citations
••
TL;DR: Protection against intoxication in cellular and animal studies were not as effective as in previous studies, but partial toxin neutralization was observed in animals, demonstrating the feasibility of using plant-virus nanoparticles as a platform for epitope defined anthrax vaccines.
16 citations
••
TL;DR: This research successfully inserted the 2β2-2β3 loop of PA into the major immunodominant region (MIR) of hepatitis B virus core (HBc) protein, and removed amino acids 79-81 from the HBc MIR of theHBcL2, leading to the full protection of the immunized mice against a lethal dose anthrax toxin challenge.
16 citations