Showing papers on "Anticipation (genetics) published in 1987"
Journal Article•
TL;DR: Megacolon is a rare complication of pregnancy that may require genetic counseling, anticipation of dystocia and a search for an underlying serious medical disease, the presenting symptom of which may be chronic constipation.
Abstract: Megacolon is a rare complication of pregnancy. Its presence during pregnancy may require genetic counseling, anticipation of dystocia and a search for an underlying serious medical disease, the presenting symptom of which may be chronic constipation. Pharmacologic treatment is not usually successful, and the colon can best be kept clean with enemas and disimpaction.
11 citations
TL;DR: By the aggressive management of acute severe asthma in children, the incidence of complications can be reduced, the length of hospital stay shortened and substantial morbidity and possible mortality minimized.
Abstract: Summary
Acute severe asthma in children should be managed by immediate attention to the patient's clinical condition. Careful observation, the use of sequential pulmonary function tests and appropriate blood gas studies will facilitate evaluation of severity. Therapy should be directed at the reversal and7sol;or correction of these abnormalities as well as anticipation of early treatment of potential complications. By the aggressive management of this condition, the incidence of complications can be reduced, the length of hospital stay shortened and substantial morbidity and possible mortality minimized.
8 citations
TL;DR: The family segregating the myotonic dystrophy gene and a t(5;8) reciprocal translocation presented the characteristics typically seen in this disease, i.e. full penetrance, broad expressivity, apparent anticipation in successive generations, presence of a congenital form transmitted by a carrier mother.
Abstract: We report on a family segregating the myotonic dystrophy (DM) gene and a t(5;8) reciprocal translocation. The DM presented the characteristics typically seen in this disease, i.e. full penetrance, broad expressivity, apparent anticipation in successive generations, presence of a congenital form transmitted by a carrier mother. The family was uninformative for linkage studies with the Lutheran and Secretor loci. The concordance between DM and chromosome translocation in 8 out of 9 individuals at risk was apparently due to chance.
2 citations