Topic
Antimicrobial peptides
About: Antimicrobial peptides is a research topic. Over the lifetime, 10645 publications have been published within this topic receiving 507688 citations. The topic is also known as: host defense peptide & antimicrobial protein.
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TL;DR: Six antimicrobial peptides, named gaegurins, were isolated from the skin of a Korean frog, Rana rugosa, and their amino acid sequences were determined by automated Edman degradation, providing the potential for application of these peptides to effective therapeutic agents for control of pathogenic microorganisms.
160 citations
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TL;DR: Understanding this liver–gut axis including the underlying mechanisms could help to find new treatment avenues, and compromised Paneth cell antimicrobial host defense seems to predispose to BT in experimental cirrhosis.
160 citations
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TL;DR: This review focuses on antimicrobial proteins and peptides of the oral cavity and on their role in periodontal disease and the potential use of antimicrobial peptides as templates for novel antibiotics.
Abstract: Antimicrobial proteins and peptides constitute a diverse class of host-defense molecules that act early to combat invasion and infection with bacteria and other microorganisms. These peptides have engendered considerable interest in the past decade as a biological paradigm in innate immunity and as a potential source of novel antibiotics. Many recent reviews have explored the biological diversity and function of this class of peptides [e.g. (36, 50, 73, 80, 103, 126, 127, 191, 209, 221, 226, 255)]. This review focuses especially on antimicrobial proteins and peptides of the oral cavity and on their role in periodontal disease. The potential use of antimicrobial peptides as templates for novel antibiotics is also discussed.
159 citations
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TL;DR: An overview of natural animal anti-microbials is presented, with an emphasis on those isolated from invertebrates, and their possible use as alternative drugs to chemical antibiotics is discussed.
159 citations
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TL;DR: Discovery of the inducibility of many antimicrobial peptides may also lead to the development of compounds that elicit epithelial defense reactions by stimulating the synthesis of endogenous peptide antibiotics.
159 citations