Topic
Antimicrobial peptides
About: Antimicrobial peptides is a research topic. Over the lifetime, 10645 publications have been published within this topic receiving 507688 citations. The topic is also known as: host defense peptide & antimicrobial protein.
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TL;DR: It is confirmed that at micromolar concentrations human beta-defensin-2 has a broad spectrum of antimicrobial activity, with the striking exception of Staphylococcus aureus.
349 citations
TL;DR: Based on the "carpet" mechanism and the role of the peptide oligomeric state, a novel group of diastereomeric (containing D- and L-amino acids) antimicrobial peptides were developed and may serve as promising templates for the future designs of antimacterial peptides.
349 citations
TL;DR: Several magainin analogs with different charges (0 to +6) and hydrophobicities are synthesized and systematically studied their interactions with the outer and inner membranes of three species of Gram-negative bacteria, indicating the importance of electrostatic interactions.
349 citations
TL;DR: Antibacterial peptide gene expression after Erwinia infection is reduced in two Drosophila mutants that have reduced numbers of hemocytes, suggesting that blood cells play a role in regulating Drosophile antimicrobial responses and also illustrating that this Dosophila-Erwinia interaction provides a powerful model for dissecting host-pathogen relationships.
Abstract: Although Drosophila possesses potent immune responses, little is known about the microbial pathogens that infect Drosophila. We have identified members of the bacterial genus Erwinia that induce the systemic expression of genes encoding antimicrobial peptides in Drosophila larvae after ingestion. These Erwinia strains are phytopathogens and use flies as vectors; our data suggest that these strains have also evolved mechanisms for exploiting their insect vectors as hosts. Erwinia infections induce an antimicrobial response in Drosophila larvae with a preferential expression of antibacterial versus antifungal peptide-encoding genes. Antibacterial peptide gene expression after Erwinia infection is reduced in two Drosophila mutants that have reduced numbers of hemocytes, suggesting that blood cells play a role in regulating Drosophila antimicrobial responses and also illustrating that this Drosophila-Erwinia interaction provides a powerful model for dissecting host-pathogen relationships.
347 citations
TL;DR: These peptides are claimed to be health enhancing nutraceuticals for food and pharmaceutical preparations and have already been considered for application both as dietary supplements in ‘functional foods’ and as drugs.
347 citations