Topic
Antimicrobial peptides
About: Antimicrobial peptides is a research topic. Over the lifetime, 10645 publications have been published within this topic receiving 507688 citations. The topic is also known as: host defense peptide & antimicrobial protein.
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TL;DR: Peptides corresponding to these sequences have been chemically synthesized and shown to exert a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi and fungi.
245 citations
TL;DR: This review focuses on in vivo studies relating how organisms - bacteria, plants, insects and mammals - employ AMPs in their interactions with microbial competitors, pathogens and symbionts.
245 citations
TL;DR: The findings show that a highly amphipathic nature is not desirable in the design of constrained cyclo(VKLKVd-YPLKVKLd-YP) peptides and that an optimum amphipATHicity can be defined by systematic enantiomeric substitutions.
244 citations
TL;DR: Mucosal antimicrobial peptides are present in lung secretions of premature and mature newborns and probably represent effector molecules of the respiratory defense system.
Abstract: Pneumonia and systemic infection are common in premature infants. The antimicrobial peptides human β -defensin 1 and 2 (hBD-1 and hBD-2) and the cathelicidin LL-37/hCAP-18 are effector molecules of the innate respiratory immune system. It is unknown whether these host defense substances are produced in the respiratory tract of newborns. Concentrations of these peptides were determined in tracheal aspirates of mechanically ventilated newborn infants. All three antimicrobial peptides could be detected in airway lining fluid with equivalent levels in term and preterm newborns. Concentrations of antimicrobial peptides correlated with each other and with levels of interleukin-8 and tumor necrosis factor- α in the bronchoalveolar lavage fluid. Pulmonary or systemic infections were associated with significantly increased concentrations of LL-37, hBD-1, and hBD-2. Western blotting detected mature peptides in the lavage fluid. In conclusion, mucosal antimicrobial peptides are present in lung secretions of prematur...
243 citations
TL;DR: In conclusion, LL-37 induces wound healing, proliferation, and migration of airway epithelial cells, and the peptide is likely involved in the regulation of tissue homeostasis in the airways.
Abstract: Antimicrobial peptides are endogenous antibiotics that directly inactivate microorganisms and in addition have a variety of receptor-mediated functions. LL-37/hCAP-18 is the only cathelicidin found...
243 citations