Topic
Antitussive Agent
About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.
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TL;DR: Over the counter cough medicines for acute cough cannot be recommended because there is no good evidence for their effectiveness and the effect sizes were small and of doubtful clinical relevance.
Abstract: Objectives To determine whether over the counter cough medicines are effective for acute cough in adults. Design Systematic review of randomised controlled trials.
162 citations
TL;DR: AV was shown to have a good antitussive activity and was 1/20-1/40 as active as codeine on mechanically and electrically induced coughing in rabbits and guinea-pigs.
147 citations
135 citations
TL;DR: For example, this paper found that mucolytic agents are not consistently effective in ameliorating cough in patients with bronchitis, although they may be of benefit to this population in other ways.
125 citations
TL;DR: It is demonstrated, for the first time, that compounds 1 and 5 showed significant antitussive activities in guinea pig after cough induction by citric acid aerosol stimulation.
Abstract: Bioactivity-directed fractionation of the crude extract of Stemona tuberosa led to the isolation and characterization of four new stenine-type Stemona alkaloids, namely tuberostemonine J ( 2), tuberostemonine H ( 3), epi-bisdehydrotuberostemonine J ( 4) and neostenine ( 5), together with the known neotuberostemonine ( 1). These five isolated alkaloids were examined for antitussive activity in guinea pig after cough induction by citric acid aerosol stimulation. In this report, we demonstrated, for the first time, that compounds 1 and 5 showed significant antitussive activities. Further study of the structure-activity relationship on these isolated alkaloids and two synthetic analogues revealed that the saturated tricyclic pyrrolo[3,2,1- jk] benzazepine nucleus is the primary key structure contributing to the antitussive activity and all cis configurations at the three ring junctions are the optimal structure for the antitussive activity of stenine-type Stemona alkaloids.
121 citations