Showing papers on "Antitussive Agent published in 2005"
TL;DR: Results indicated an antitussive effect of Carum copticum which was even greater than that of codeine at concentrations used, and was not due to its main constituent, carvacrol.
58 citations
TL;DR: Intratracheal administration of lidocaine (final concentration, 0.66%) proved to be the most reliable method to reduce frequency and intensity of coughing in horses during BAL.
Abstract: Objective—To determine whether treatment of horses with antitussive agents before bronchoalveolar lavage (BAL) reduces the frequency and intensity of the cough reflex during BAL. Animals—8 healthy horses. Procedure—Standard BAL was performed on each horse weekly for 6 weeks. Detomidine was used as a general sedative, and various antitussive agents were evaluated for their suitability to suppress undesirable coughing. Treatments administered prior to BAL consisted of saline (0.9% NaCl) solution (control treatment), codeine, butorphanol tartrate, glycopyrrolate, lidocaine hydrochloride (final concentration, 0.33%), and lidocaine hydrochloride at a final concentration of 0.66% (lidocaine 0.66%). Frequency and intensity of coughing were digitally recorded throughout the BAL procedure. The volume of BAL fluid collected was measured, and the fluid was cytologically examined to assess potential effects of the medications on composition. Results—Coughing frequency was significantly reduced after intratracheal adm...
19 citations
TL;DR: Four urinary metabolites in human urine showed peaks with the same chromatographic retention times and mass spectra in LC/MS/MS as synthetic substances 2, 3, 4 and 5, which are inactive in the antitussive effect.
Abstract: Identification of some benproperine metabolites in humans and investigation of their antitussive effect
7 citations