Showing papers on "Antitussive Agent published in 2007"

The antitussive activity of polysaccharides from Althaea officinalis l., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch.

Abstract: Background The therapy of pathological type of cough presents serious medical problem. Objectives The aim of experiments was to investigate polysaccacharide influence on experimentally induced cough. Methods The purified and/or modified polysaccharides from the flowers and plants, characterized by chemical composition and molecular properties were subjected to tests for antitussive activity on cough, induced mechanically in conscious cats of both sexes. Results The results revealed that the tested polysaccharides exhibited statistically significant cough-suppressing activity, which was noticeably higher than that of the non-narcotic drug used in clinical practice to treat coughing. The most expressive antitussive activity was observed with the polysaccharide from marsh mallow, containing the highest proportion of the uronic acid constituent. Negative influence of the tested compounds on expectoration was negligible when compared to that of codeine. Conclusion Antitussive activity of various plant polysaccharides was confirmed. These results allow ranging them among prospective antitussive agents (Tab. 2, Fig. 6, Ref. 15) Full Text (Free, PDF) www.bmj.sk.

Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats

Abstract: Nosaoova G., J. Mokr˘, A. Ather, M.T.H. Khan: Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats. Acta Vet. Brno 2007, 76: 27-33. The aim of the present study was to examine the antitussive activity of the ethanolic extract of Paederia foetida (P. foetida) in conscious cats by mechanical stimulation of laryngopharyngeal (LP) and tracheobronchial (TB) mucous areas of airways. The results showed that the ethanolic extract of P. foetida at the oral dose of 200 mg·kg-1 b.w. had a cough-suppressive effect. It caused a significant (p < 0.05) decrease of the number of cough efforts (NE) and frequency of cough (NE.min-1) from both LP and TB areas. The intensity of a cough attack was significantly decreased only during inspirium (IA - ). Also a significant (p < 0.05) decrease was observed of the intensity of maximal effort in expirium (IME+) from TB area and inspirium (IME - ) from both LP and TB areas. The antitussive activity of the ethanolic extract of P. foetida was lower than that of the classical narcotic antitussive drug - codeine, but similar to that of the non-narcotic antitussive agent dropropizine. The antitussive activity of the ethanolic extract of P. foetida may be connected with its previously demonstrated anti-inflammatory activity.

Combination cough treatment compounds and method of treating common coughs

Abstract: A novel composition of three recognized antitussive agents, when used in combination, work in an additive fashion to suppress cough. Each drug has a desirable effect of suppressing cough in a unique fashion. However, undesirable side effects can occur in humans at concentrations at which the drug has its maximal antitussive effect. Pharmaceutical compositions of theobromine, dextromethorphan, and an antihistamine with central nervous system effect, such as dexbrompheniramine, maximize cough suppression while decreasing the likelihood of side effects when used in combination.

Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent

Abstract: Aim: To seek a novel and potent antitussive drug based on Shedan—Chuanbei powder, a complex of traditional Chinese medicine preparation for cough therapy. Methods: Verticinone—cholic acid (Ver—CA) salt, a novel, salifying derivative of verticinone and cholic acid, both of which are the major bioactive components in Shedan—Chuanbei powder, was synthesized. We then evaluated the antitussive activity and the acute toxicity of the salt. Results: The new compound, with good solubility in water, has much more potent antitussive activity in comparison with the same dose of single verticinone and single cholic acid. The administration 3 mg/kg of Ver—CA could result in over 50% reduction of a citric acid-induced cough. Pretreatment with naloxone (0.8 mg/kg, ip) can only partially antagonize its anti-tussive effect. On the other hand, glybenclamide (3 mg/kg, ip), an ATP-sensitive K + channel blocker, can also significantly reduce the antitussive effect of Ver—CA. A further acute toxicity study showed that the LD50 values of Ver—CA were 3 times that of verticinone. Conclusion: Based on the studies of pharmacology and acute toxicity, the salt has a synergic and attenuated toxicity compared with single verticinone and cholic acid. Moreover, the present study also suggests that Ver—CA, a potential novel antitussive agent, may exert its antitussive effect via both the peripheral (modulated by ATP-sensitive K + channels) and central mechanisms (modulated by the opioid receptor).

Non-steroid antiphlogistics against coughing

Abstract: The present invention relates to the use of a non-steroid antiphlogistic for the treatment of unproductive coughing caused by viruses or bacteria, or to the production of a preparation for the treatment of unproductive coughing due to viruses or bacteria, respectively, and to a pharmaceutical formulation for the treatment of unproductive coughing, comprising a combination of at least one non-steroid antiphlogistic having at least one antitussive agent.