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Showing papers on "Antitussive Agent published in 2010"


Journal ArticleDOI
TL;DR: The results suggest that cough as a side-effect of ACEi is not recognized as being ACEi-related or is symptomatically treated with antitussive agents instead of recommended ACEi substitution.
Abstract: AIMS Angiotensin-converting enzyme inhibitors (ACEi) are frequently prescribed for various cardiovascular and renal diseases. A common side-effect of these drugs is a persistent dry cough. Physicians who fail to recognize a dry cough to be ACEi-related may attempt to treat it with antitussive agents instead of recommended ACEi substitution. Prescription behaviour in the general population considering treatment of the side-effect with antitussive agents has not been studied before. METHODS Drug dispensing data between 2000 and 2007 were retrieved from the IADB.nl database. A prescription sequence symmetry analysis was used to determine whether antitussive agents were prescribed more often following ACEi initiation than the other way around. A logistic regression model was fitted to determine predictors. RESULTS We identified 27 446 incident users of ACEi therapy. One thousand and fifty-four patients were incident users of both ACEi and antitussives within a half-year time span. There was an excess of patients being prescribed antitussive agents after ACEi initiation (703 vs. 351), adjusted sequence ratio 2.2 [confidence interval (CI) 1.9, 2.4]. Female patients were more likely to be prescribed antitussive agents following ACEi therapy initiation, odds ratio 1.4 (CI 1.1, 1.9), age and co-medications were not significant predictors. CONCLUSIONS There was a significant and clinically relevant excess of patients receiving antitussives after ACEi initiation. The results suggest that cough as a side-effect of ACEi is not recognized as being ACEi-related or is symptomatically treated with antitussive agents instead of ACEi substitution. The estimated frequency of antitussive treatment of ACEi-induced dry cough is 15%.

62 citations


Journal ArticleDOI
TL;DR: Croomine acts on central sites in the cough reflex pathway and demonstrates central respiratory depressant effects, which can partly account for the adverse reactions reported for the herb.

38 citations


Journal ArticleDOI
TL;DR: It has been proved that the 60% ethanol and 90% ethanol fraction were curatively effective on expectoration and coughing, respectively both at the high and middle dose, which supplied proofs for the further research on chemical constituents in both of two effective fractions.

24 citations


Journal ArticleDOI
TL;DR: The study confirmed the central antitussive effect of codeine, but showed a low sensitivity of sneeze and expiration reflex to codeine.
Abstract: Background Codeine represents a commonly used drug to suppress cough Central antitussive effect of codeine has been confirmed in a number of animal studies However, available data related to antitussive activity of codeine in rabbits are very limited

20 citations


01 Jan 2010
TL;DR: This review is intended to describe the current status of plant used as antitussive and expectorant and their active compounds with cough-suppressing activity.
Abstract: The problems emerging from the treatment of cough during many types of respiratory diseases by conventional opioid antitussive agents, such as codeine and codeine-like compounds. Medicinal plants are potential source of substances with high-antitussive efficiency with minimal unwanted effects. Recent trends of modern phytotherapy include specification of active substances responsible for therapeutic effect as well as their quantification in the healing drugs, which enables the treatment rationalization, especially the dosing and pursuing of adverse effects. This review is intended to describe the current status of plant used as antitussive and expectorant and their active compounds with cough-suppressing activity.

14 citations


Journal ArticleDOI
TL;DR: The authors showed that a β2-agonist, terbutaline (0–3 mg·kg−1), dose-dependently inhibited 10−4 M capsaicin-induced cough in conscious guinea pigs and concluded thatβ2-agonists are antitussive and directly inhibit sensory nerve activation.
Abstract: To the Editors: We read with great interest the paper by Freund-Michel et al. 1 in a recent issue of the European Respiratory Journal , because the results are inconsistent with the medical common sense that β2-agonists do not have common antitussive property. The authors showed that a β2-agonist, terbutaline (0–3 mg·kg−1), dose-dependently inhibited 10−4 M capsaicin-induced cough in conscious guinea pigs. Terbutaline also blocked sensory nerve activation. They concluded that β2-agonists are antitussive and directly inhibit sensory nerve activation. We have shown that the number of 10−4 M capsaicin-induced coughs was extremely increased 24 h after …

5 citations


Journal Article
TL;DR: This is one of the rare reported cases of baboon syndrome associated with use of an antitussive-decongestant including pseudoephedrine HCI, dextromethorphan HBr and chlorpheniramine maleate.
Abstract: We present the case of a three-year-old boy who developed a special exanthem after oral intake of an antitussive-decongestant agent. The clinical findings were compatible with baboon syndrome. To our knowledge, this is one of the rare reported cases of baboon syndrome associated with use of an antitussive-decongestant including pseudoephedrine HCI, dextromethorphan HBr and chlorpheniramine maleate.

5 citations


01 Jan 2010
TL;DR: In this article, methanol extract of Sphaeranthus (S.) indicus Linn. (Family- Asteraceae) plants was investigated for its effect on a cough model induced by sulphur dioxide gas and for its synergistic effect of sleeping time induced by standard sedatives in mice.
Abstract: The present study was carried out to elucidate the potential of, methanol extract of Sphaeranthus (S.) indicus Linn. (Family- Asteraceae) plants on antitussive activity and synergistic effects of sleeping time induced by standard sedatives using Swiss albino mice. The dried, powdered plants of, S. indicus were extracted successively with petroleum ether (60–800C), chloroform and methanol in soxhlet apparatus. The methanol extract (yield 7.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Antitussive activity of the MESI was investigated for its effect on a cough model induced by sulphur dioxide gas and also investigated for its synergistic effect of sleeping time induced by standard sedatives in mice. Results were revealed that the MESI was found to produce significant antitussive activity (P<0.001) when compared with control and codeine phosphate in a dose dependent manner. The MESI of (200, 300 and 400 mg/kg) showed maximum inhibition of cough by 71.24%, 76.84% and 77.92% and also exhibited significant synergistic effect (P<0.001) at the dose levels of 200, 250 and 300 mg/kg when compared with control and standard sedative pentobarbitone and diazepam. It concludes that, MESI possessed remarkable antitussive effect, which provides pharmacological evidence in support of folklore-claim of S. indicus as an antitussive agent. The MESI administered alone at any dose levels was not producing any sedative action. When the MESI was administered prior to the administration of standard sedatives, it produces significant synergistic effects three times greater than that of standard sedatives in mice.

4 citations