Showing papers on "Antitussive Agent published in 2013"
TL;DR: Placebo-related decreases in urge-to-cough are accompanied by commensurate decreases in several brain regions activated during capsaicin inhalation, suggesting that beliefs about treatment can modify the central processing of inputs arising from the airways.
Abstract: Rationale: Antitussive therapies are accompanied by a substantial placebo effect, indicating that inhibitory circuits in the brain have a significant capacity to regulate cough neural processing. However, essentially nothing is known about the identity of these inhibitory circuits or how they reduce coughing. Understanding these processes may help develop more effective antitussive therapies in the future.Objectives: To identify regional changes in human brain activity related to the urge-to-cough after placebo antitussive administration.Methods: Seventeen healthy participants undertook functional magnetic resonance imaging while completing a series of inhalations of capsaicin to induce the urge-to-cough. The resultant brain responses associated with capsaicin inhalation without any treatment were compared with those induced by capsaicin after placebo antitussive administration.Measurements and Main Results: There was a significant decrease in participants’ ratings of urge-to-cough after the placebo antit...
55 citations
01 Jan 2013
TL;DR: It is concluded that Le.cr possessed remarkable antitussive effect, which provides pharmacological evidence in support of folklore-claim of Lycopus europaeus as an antitussives agent.
Abstract: The present study was carried out to elucidate the potential of, methanol extract of Lycopus europaeus plant on antitussive activity in albino mice. The methanol extract (yield 12.5% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Antitussive activity of the methanolic extract of Lycopus europaeus (Le.cr) was investigated for its effect on a cough model induced by sulphur dioxide gas and Ammonium liquor induced cough in mice. Results were revealed that the Le.cr was found to produce significant antitussive activity (P<0.001) when compared with control, codeine phosphate and Dextramethorphane in a dose dependent manner. High dose of Le.cr of (500 mg/kg) showed maximum inhibition of cough by 61.21% and 56.63% induced by both inducers. It concludes that Le.cr possessed remarkable antitussive effect, which provides pharmacological evidence in support of folklore-claim of Lycopus europaeus as an antitussive agent.
13 citations
TL;DR: This regulation of cough through sensory nerves of the Ad fibres or C-fibres, and through recently-discovered channels such as the acid-sensing ion channels (ASIC), transient receptor potential channels (TRP) such as TRPV1 and TRPA1, and some specific voltage-gated sodium channels are described in four reviews.
4 citations
Journal Article•
TL;DR: The herbal formulations demonstrated significant antitussive activity in sulphur dioxide induced cough model in rats, and exhibited cough inhibitions of between 15 and 27%, and 14 and 38%, with respect to the control group, 30 and 60 minutes after sample administration respectively.
Abstract: Background: Cough is an important defensive pulmonary reflex that removes irritants, fluids or foreign materials from the airways. Frequently, cough is non-productive and requires suppression and opioid receptor agonists such as codeine are commonly used as antitussive agents. However, opioids produce side effects that include sedation, addiction potential and constipation. Novel cough suppressant therapies should maintain or improve upon the antitussive efficacy profile of opioids but with minimum or no side effects. Objective: To evaluate antitussive activity of combination of herbal medicines as formulations in sulphur dioxide - induced cough model in rats. Methodology: Wister rats of either sex, weighing 150 - 200 g, were divided into 7 groups (n = 6). Group 1 served as a control and received normal saline, groups 2 received codeine phosphate, group 3 and 4 received the coded market samples and groups 5, 6 and 7 received the test samples, respectively. Thirty or sixty minutes following administration, the rats were exposed to sulphur dioxide gas for 1 minute and then placed in an open chamber for counting of cough bouts. Results: The formulations exhibited cough inhibitions of between 15 and 27%, and 14 and 38%, with respect to the control group, 30 and 60 minutes after sample administration respectively. Conclusion: The herbal formulations demonstrated significant (p < 0.05) antitussive activity in sulphur dioxide induced cough model. Key words: Antitussive activity; herbal formulations; sulphur dioxide; cough
3 citations