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Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.


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Journal ArticleDOI
Junzo Kamei1
TL;DR: It is demonstrated that delta-opioid receptor antagonists, such as naltrindole and 7-benzylidenenaltrexone, produced potent antitussive effects, which may be mediated by the antagonism of delta(1)-, but not delta(2)-opIOid receptors.

25 citations

Journal ArticleDOI
TL;DR: Recent research in the field of cough has resulted in the development of several new classes of compounds that may prove to be clinically useful peripherally-acting antitussives.

25 citations

Journal ArticleDOI
TL;DR: Several derivatives had approximately the same potency as codeine when given subcutaneously to guinea‐pigs; one of these, dicholine glycyrrhetinic acid hydrogen succinate, exhibited the same degree of activity after oral administration.
Abstract: The antitussive activity of 18β-glycyrrhetinic acid has been investigated using chemical stimulation in the unanaesthetised guinea-pig and electrical stimulation in the lightly anaesthetised cat. Derivatives of glycyrrhetinic acid were active in both types of experiment indicating a central antitussive effect. Several derivatives had approximately the same potency as codeine when given subcutaneously to guinea-pigs; one of these, dicholine glycyrrhetinic acid hydrogen succinate, exhibited the same degree of activity after oral administration

25 citations

Journal ArticleDOI
TL;DR: The methanol extract of Leucas lavandulaefolia was investigated for its effects on a cough model induced by sulfur dioxide gas in mice as mentioned in this paper, and it exhibited significant antitussive activity when compared with control.

25 citations

Journal ArticleDOI
S. S. Nayak1, Animesh Ghosh1, K. Srikanth1, Bikash Debnath1, Tarun Jha1 
TL;DR: The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice and exhibited significant antitussive activity compared with the control in a dose dependent manner.
Abstract: The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited significant antitussive activity compared with the control in a dose dependent manner. The antitussive activity of the extract was compared with that of codeine phosphate, a prototype antitussive agent. The A. webbiana leaf extract (400 and 600 mg/kg) showed maximum inhibition of cough frequency by 71.69% and 78.67%, respectively, when compared with the control group and was comparable in effect to codeine phosphate.

25 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20211
20204
20185
20172
20165
20158