Topic
Antitussive Agent
About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.
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TL;DR: It is demonstrated that delta-opioid receptor antagonists, such as naltrindole and 7-benzylidenenaltrexone, produced potent antitussive effects, which may be mediated by the antagonism of delta(1)-, but not delta(2)-opIOid receptors.
25 citations
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TL;DR: Recent research in the field of cough has resulted in the development of several new classes of compounds that may prove to be clinically useful peripherally-acting antitussives.
25 citations
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TL;DR: Several derivatives had approximately the same potency as codeine when given subcutaneously to guinea‐pigs; one of these, dicholine glycyrrhetinic acid hydrogen succinate, exhibited the same degree of activity after oral administration.
Abstract: The antitussive activity of 18β-glycyrrhetinic acid has been investigated using chemical stimulation in the unanaesthetised guinea-pig and electrical stimulation in the lightly anaesthetised cat. Derivatives of glycyrrhetinic acid were active in both types of experiment indicating a central antitussive effect. Several derivatives had approximately the same potency as codeine when given subcutaneously to guinea-pigs; one of these, dicholine glycyrrhetinic acid hydrogen succinate, exhibited the same degree of activity after oral administration
25 citations
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TL;DR: The methanol extract of Leucas lavandulaefolia was investigated for its effects on a cough model induced by sulfur dioxide gas in mice as mentioned in this paper, and it exhibited significant antitussive activity when compared with control.
25 citations
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TL;DR: The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice and exhibited significant antitussive activity compared with the control in a dose dependent manner.
Abstract: The methanol extract of A. webbiana Lindl was evaluated for its effect on a cough model induced by sulphur dioxide gas in mice. When administered orally it exhibited significant antitussive activity compared with the control in a dose dependent manner. The antitussive activity of the extract was compared with that of codeine phosphate, a prototype antitussive agent. The A. webbiana leaf extract (400 and 600 mg/kg) showed maximum inhibition of cough frequency by 71.69% and 78.67%, respectively, when compared with the control group and was comparable in effect to codeine phosphate.
25 citations