Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.

Antitussive properties of butorphanol.

Abstract: Butorphanol (levo-N-cyclobutylmethyl-3, 14-dihydroxy morphinan), a potent analgetic agent of the narcotic antagonist type with a low abuse potential in laboratory animals, was evaluated for antitussive activity in unanesthetized guinea-pigs and dogs. Subcutaneously, it was over 100 times more active than codeine, dextromethorphan and dl-pentazocine and about 20 times more active than morphine in the guinea-pig, while in the dog it was 100, 10 and 4 times more active than codeine, dl-pentazocine and morphine, respectively. Orally, butorphanol was 15-20 times more active than either codeine or dextromethrophan in both species. Naloxone reversed the antitussive effects of butorphanol, codeine, morphine and dl-pentazocine while those of dextromethorphan were not antagonized. The antitussive effect of butorphanol and morphine lasted about 4 hr and both compounds were longer acting than codeine. Butorphanol was also shown to be as effective against cough of pathological origin as against experimentally induced cough in the dog.

Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough.

Abstract: The antitussive effects of dextromethorphan (30 mg) + salbutamol (2 mg), dextromethorphan (30 mg) alone and placebo on artificial cough induced by citric acid were compared in 19 healthy non-smoking v

Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats

Abstract: Nosaoova G., J. Mokr˘, A. Ather, M.T.H. Khan: Antitussive Activity of the Ethanolic Extract of Paederia foetida (Rubiaceae family) in Non-Anaesthetized Cats. Acta Vet. Brno 2007, 76: 27-33. The aim of the present study was to examine the antitussive activity of the ethanolic extract of Paederia foetida (P. foetida) in conscious cats by mechanical stimulation of laryngopharyngeal (LP) and tracheobronchial (TB) mucous areas of airways. The results showed that the ethanolic extract of P. foetida at the oral dose of 200 mg·kg-1 b.w. had a cough-suppressive effect. It caused a significant (p < 0.05) decrease of the number of cough efforts (NE) and frequency of cough (NE.min-1) from both LP and TB areas. The intensity of a cough attack was significantly decreased only during inspirium (IA - ). Also a significant (p < 0.05) decrease was observed of the intensity of maximal effort in expirium (IME+) from TB area and inspirium (IME - ) from both LP and TB areas. The antitussive activity of the ethanolic extract of P. foetida was lower than that of the classical narcotic antitussive drug - codeine, but similar to that of the non-narcotic antitussive agent dropropizine. The antitussive activity of the ethanolic extract of P. foetida may be connected with its previously demonstrated anti-inflammatory activity.

Central antitussive effect of codeine in the anesthetized rabbit

Abstract: Background Codeine represents a commonly used drug to suppress cough Central antitussive effect of codeine has been confirmed in a number of animal studies However, available data related to antitussive activity of codeine in rabbits are very limited

Insulin-dependent diabetes mellitus induced by the antitussive agent dextromethorphan.

Abstract: 0±9, 21.7 % in the age group 20 years or over). The highest odds ratio (OR) was found in patients aged 0±9 years, able to generate 4 heterodimers (OR 161.3, 95 % CI 39.3±662.7). Therefore, our study confirms on a well-defined population-based cohort an age-dependent gradient of DQA1 and DQB1 susceptibility genes. In addition we found a higher prevalence of patients able to generate 0 heterodimers in adult-onset than in childhood-onset diabetes. In different populations, patients able to generate 0 heterodimers are at lower risk than those with 4 heterodimers. Inefficiency in the interaction between peptide antigens and HLA class II molecules are probably involved in these findings. Structural and functional analysis of the HLA class II susceptibility genes has been carried out and molecular mechanisms have been suggested for several of the key steps in the autoimmune insulitis [6]. Our finding of lower prevalence of susceptible heterodimers in adult-onset than in childhood-onset Type I diabetes could suggest either the involvement of other loci in the genetic susceptibility of the disease in adults or heterogeneity of environmental determinants by age at onset of the disease.