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Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.


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Journal ArticleDOI
TL;DR: A review of the current understanding of the pathogenesis of cough and the hypertussive state characterizing a number of diseases as well as reviewing the evidence for the different classes of antitussive drug currently in clinical use can be found in this paper.
Abstract: Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, and as a problem in its own right in patients with chronic cough of unknown origin. This article reviews our current understanding of the pathogenesis of cough and the hypertussive state characterizing a number of diseases as well as reviewing the evidence for the different classes of antitussive drug currently in clinical use. For completeness, the review also discusses a number of major drug classes often clinically used to treat cough but that are not generally classified as antitussive drugs. We also reviewed a number of drug classes in various stages of development as antitussive drugs. Perhaps surprising for drugs used to treat such a common symptom, there is a paucity of well-controlled clinical studies documenting evidence for the use of many of the drug classes in use today, particularly those available over the counter. Nonetheless, there has been a considerable increase in our understanding of the cough reflex over the last decade that has led to a number of promising new targets for antitussive drugs being identified and thus giving some hope of new drugs being available in the not too distant future for the treatment of this often debilitating symptom.

119 citations

Journal ArticleDOI
Dongdong Wang1, Shu Wang1, Xiong Chen1, Xiaolong Xu1, Jingyi Zhu1, Lihuan Nie1, Xia Long1 
TL;DR: Evidence is provided for Bulbus Fritillaria Cirrhosae to be used as an antitussive and expectorant Traditional Chinese Medicine (TCM) drug and the structures of the four alkaloids isolated from BFW were confirmed.

116 citations

Journal ArticleDOI

109 citations

Journal ArticleDOI
TL;DR: Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern.
Abstract: The present study was conducted to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern. Electromyograms of diaphragm and rectus abdominis muscle...

98 citations

Journal ArticleDOI
Junzo Kamei1
TL;DR: The results indicate that the antitussive effects of opioids are mediated predominantly by mu- and kappa-opioid receptors, and suggest that sigma sites may be involved in the antitussedive mechanism of non-narcotic antitussives.

94 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20211
20204
20185
20172
20165
20158