Topic
Antitussive Agent
About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.
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TL;DR: This report-the third of a series on codeine and its alternates for pain and cough relief-presents a detailed review of the physiology and pathophysiology of cough, the methods for the experimental and clinical measurement of the antitussive action of drugs, possible mechanisms of action of antitussives agents, and includes a compilation of experimental results and clinical experience with codeine as an antitussIVE.
Abstract: This report-the third of a series on codeine and its alternates for pain and cough relief-presents a detailed review of the physiology and pathophysiology of cough, the methods for the experimental and clinical measurement of the antitussive action of drugs, possible mechanisms of action of antitussive agents, and includes a compilation of experimental results and clinical experience with codeine as an antitussive.
67 citations
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TL;DR: This technique may offer a useful screening test for the activity of new potential antitussive compounds in man after ingestion of codeine 20 mg, dextromethorphan 30mg, noscapine 30 mg, and placebo against citric acid-induced cough.
Abstract: 1. Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects. 2. Drug differences occurred at 2 1/2 h following ingestion of the drugs but not at 1 1/4 h. 3. Only codeine 20 mg had a greater antitussive action than placebo, but dextromethorphan 30 mg also did not differ from codeine 20 mg. 4. This technique may offer a useful screening test for the activity of new potential antitussive compounds in man.
67 citations
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65 citations
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64 citations
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TL;DR: The results showed that the cough suppressive activity of E. officinalis is dose-dependent, and a higher dose of this substance perorally was more effective, especially in decreasing the number of cough efforts, frequency of cough, and the intensity of cough attacks in inspirium and expirium was more pronounced.
63 citations