Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.

Morphinan derivatives for use as antitussive agents

Abstract: Disclosed is an antitussive agent which is applicable to the treatment or prevention of cough. The antitussive agent comprises, as an active ingredient, a specific morphinan derivative having a nitrogenated cyclic substituent such as [N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy- morphinan-6β-yl)-3,4,5,6-tetarhydrophthalimide] shown by the formula below or a pharmacologically acceptable acid addition salt thereof. The antitussive agent has an excellent therapeutic or prophylactic effect on cough and produces little adverse side effects. [Chemical formula]

Baboon syndrome induced by oral antitussive-decongestant agent in a child.

Abstract: We present the case of a three-year-old boy who developed a special exanthem after oral intake of an antitussive-decongestant agent. The clinical findings were compatible with baboon syndrome. To our knowledge, this is one of the rare reported cases of baboon syndrome associated with use of an antitussive-decongestant including pseudoephedrine HCI, dextromethorphan HBr and chlorpheniramine maleate.

Research paper Antitussive and synergistic effects of sleeping time induced by standard sedatives of Sphaeranthus indicus plant extracts

Abstract: The present study was carried out to elucidate the potential of, methanol extract of Sphaeranthus (S.) indicus Linn. (Family- Asteraceae) plants on antitussive activity and synergistic effects of sleeping time induced by standard sedatives using Swiss albino mice. The dried, powdered plants of, S. indicus were extracted successively with petroleum ether (60–800C), chloroform and methanol in soxhlet apparatus. The methanol extract (yield 7.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Antitussive activity of the MESI was investigated for its effect on a cough model induced by sulphur dioxide gas and also investigated for its synergistic effect of sleeping time induced by standard sedatives in mice. Results were revealed that the MESI was found to produce significant antitussive activity (P<0.001) when compared with control and codeine phosphate in a dose dependent manner. The MESI of (200, 300 and 400 mg/kg) showed maximum inhibition of cough by 71.24%, 76.84% and 77.92% and also exhibited significant synergistic effect (P<0.001) at the dose levels of 200, 250 and 300 mg/kg when compared with control and standard sedative pentobarbitone and diazepam. It concludes that, MESI possessed remarkable antitussive effect, which provides pharmacological evidence in support of folklore-claim of S. indicus as an antitussive agent. The MESI administered alone at any dose levels was not producing any sedative action. When the MESI was administered prior to the administration of standard sedatives, it produces significant synergistic effects three times greater than that of standard sedatives in mice.

Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]. 2nd communication: investigations on theophylline-like activities.

Abstract: CH-13584 (formerly: KHL-8425, 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl], CAS 115779-20-9) is a new xanthine derivative, structurally related to theophylline. Potent antitussive activity in the 4 to 8 mg/kg dose range, by the oral route, was already demonstrated for this compound. In the present work, it is shown that contrary to theophylline, CH-13584 does not interact with adenosine A 1 receptor and is a weaker inhibitor of cyclic nucleotide phosphodiesterase. In addition, CH-13584 is a less active bronchodilator in vitro and in vivo. It is also devoid of the cardiovascular and behaviour side-effects of theophylline and of effects on diuresis at dosage well above the antitussive dose. CH-13584, therefore, has a different pharmacological profile compared to theophylline and is devoid of the known side-effects of the latter. Such differences could result from a different biochemical profile.

An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine.

Abstract: Background Cough is one of the most common medical symptoms for which medical advice is sought. Although cough is a protective reflex responsible for clearing the airways from secretions and foreign bodies, it can be a troublesome symptom that causes discomfort to patients. Due to the increasing interest in herbal remedies in the both developed and developing countries, in the current study, we aimed to overview medicinal herbs containing essential oils used as antitussive agents according to the Traditional Persian Medicine [TPM] textbooks. We summarized the relevant scientific evidence on their possible pharmacological actions. Methods To collect the evidence for treatment of cough or "seaal" [cough in ancient books] from TPM sources, five main medicinal Persian manuscripts were studied. The antitussive herbs were listed and their scientific names were identified and authenticated in accordance with botanical reference books. ScienceDirect and PubMed online databases were searched for related mechanisms of action of the reported medicinal plants. Results The number of 49 herbs containing essential oils were recommended in TPM for the treatment of cough; 21 of them had at least one known mechanism of action for cough suppression in the scientific literature. According to this review, most of the cited medicinal plants were assessed for either nitric oxide inhibitory or antitussive/expectorant activities. Conclusion In addition to advantageous effects of antitussive herbs noted by TPM, the present review highlighted some recent evidence-based data on these promising candidates that could be used as an outline for future research on their medicinal use.