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Antitussive Agent

About: Antitussive Agent is a research topic. Over the lifetime, 380 publications have been published within this topic receiving 5776 citations.


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TL;DR: The chapter highlights some of the advances in the development of novel antitussives and reviews their chemistry, mechanism and site of action, including central site and peripheral sites of action.
Abstract: Publisher Summary This chapter presents an overview of the developments in antitussive therapy. Current antitussive therapy is dominated by the use of older drugs, such as dextromethorphan and codeine. These drugs however carry significant side effect liabilities, including among others, sedation, abuse liability, and respiratory depression. Because persistent cough is underserved by current therapeutic options available, there is an increasing need for safe and efficacious antitussive alternative(s) to existing medications. Centrally active antitussive agents act preferentially by depressing the cough center at the level of the lower brainstem without affecting peripheral sensory or motor endplate effector responses. The chapter highlights some of the advances in the development of novel antitussives and reviews their chemistry, mechanism and site of action. Concepts related to neural regulation of the cough reflex are discussed. Afferent and efferent mechanisms of the cough reflex are elaborated and site of action of antitussive drugs is described, including central site and peripheral sites of action. Centrally acting agents are elaborated and an overview of neurokinin antagonists, peripherally acting agents, and potassium channel openers is also presented.

4 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20211
20204
20185
20172
20165
20158